The purpose of this study is to examine the efficacy of dose regimen of serratiopeptidase (serodase 5 mg) as a prospective, randomized, parallel, double blind Placebo- controlled study.

A prospective, randomized, parallel, double blind Placebo- controlled study to examine the efficacy of dose regimen of serratiopeptidase (serodase 5 mg) on 112 males and females volunteers in the treatment of inflammation after third molar surgery, comparing drug treatment vs placebo over a period of 20 weeks To assess the dose effectiveness of the dose regimen of Serodase 5 mg; the primary outcomes are trismus and swelling while inflammation is a secondary outcome.the expected duration of participants participation will be around 5 days divided into 4 visits, the time point of the measurment are (0,2,4 and 5 days).

The results are expected to assess the improvement of the maximal interincisal distance, reduction of swelling and improvment in the sensation of post-operative pain.

Inclusion Criteria:

• participants presented with impacted lower wisdom tooth needs Buccaneers flap with buccal and distal bone removal.
• male or female 18-50
• participant is willing and able to give informed consent for paricipation in the study.
• Able and willing and able with all study requirments.

Exclusion Criteria:

• other oral surgical procedures during the same session except the removal of supernumerary third molars.
• female subject who is pregnant or lactating
• subjects has participated in any clinical research study within the previous 8 weeks.
• subjects on anti coagulant drugs .
• Unwilling participants to continue the study and those with abnormality of wound healing process.