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| Name | Class |
|---|---|
| IMU University, Malaysia | OTHER |
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The goal of this clinical trial is to investigate the postprandial effect of palm olein- and palm kernel oil- diets compared to PUFA-rich diet (sunflower oil in this study) on gut hormones response and appetite in healthy adults. The main questions it aims to answer are:
• Do palm olein- and palm kernel oil-diets postulate to improve satiety and lower appetite compared to PUFA rich diet (sunflower oil) in healthy adults? Researchers will compare diets prepared with palm olain or palm kernel oil to a diet prepared with sunflower oil to see the effects of these three diets on gut hormones and satiety score.
Participants will:
Please refer to the protocol uploaded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| P | Experimental | PO-PKO-SFO |
|
| Q | Experimental | PO-SFO-PKO |
|
| R | Experimental | PKO-PO-SFO |
|
| S | Experimental | PKO-SFO-PO |
|
| T | Experimental | SFO-PO-PKO |
|
| U | Experimental | SFO-PKO-PO |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Palm olein | Other | high-fat muffin prepared with 50g palm olein |
|
| Measure | Description | Time Frame |
|---|---|---|
| Glucose-dependent Insulinotropic Polypeptide (GIP) | GIP analysed using ELISA kits using plasma sample. | postprandial from baseline (0 min) to 4 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Glucagon-like Peptide 1 (GLP-1) | GLP-1 is analysed with ELISA kit using plasma. | Postprandial from baseline (0 min) to 4 hours |
| Peptide YY (PYY) | PYY is analysed with ELISA kit using plasma sample. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Malaysian Palm Oil Board | Kajang | Selangor | 43300 | Malaysia |
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| ID | Term |
|---|---|
| C000612899 | palm kernel oil |
| D000074242 | Sunflower Oil |
| ID | Term |
|---|---|
| D010938 | Plant Oils |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
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3x6 arms, crossover-designed randomised feeding intervention.
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| Palm kernel oil | Other | high-fat muffin prepared with 50g palm kernel oil |
|
| Sunflower Oil | Other | high-fat muffin prepared with 50g sunflower oil |
|
| Postprandial from baseline (0 min) to 4 hours |
| Ghrelin | Ghreli is analysed using ELISA kits using plasma sample. | Postprandial from baseline (0 min) to 4 hours |
| HOMA IR | HOMA IR will be calculated using glucose, insulin and c-peptide levels measured. | Postprandial from baseline (0 min) up to 2 hours. |
| Cholecytokinin, CCK | CCK is analysed with ELISA kit using plasma. | Postprandial from baseline (0 min) to 4 hours. |