Efficacy of Chlorhexidine and Morus Nigra Mouthwashes After Periodontal Treatment

Comparison of the Efficacy of Chlorhexidine and Morus Nigra Mouthwashes in the Treatment of Periodontal Diseases

This study aims to evaluate and compare the clinical, biochemical, and microbiological effects of chlorhexidine and Morus nigra (blackberry) mouthwashes used as an adjunct to non-surgical periodontal treatment (scaling and root planing - SRP) in patients with periodontal diseases. The participants will be divided into three groups: a control group receiving only SRP, a group receiving SRP combined with chlorhexidine mouthwash, and a group receiving SRP combined with Morus nigra mouthwash. Clinical periodontal parameters, gingival crevicular fluid levels of inflammatory markers (including TNF-a, IL-1b, and IL-10), and subgingival plaque microbiological profiles (such as red complex bacteria and Fusobacterium) will be evaluated at baseline, 1 month, and 3 months after the treatment.

Inclusion Criteria:

• Patients diagnosed with periodontitis.
• Systemically healthy individuals.
• Patients aged between 18 and 65 years.
• Presence of at least 20 natural teeth.
• Volunteering to participate in the study and signing the informed consent form.

Exclusion Criteria:

• Presence of any systemic disease that may affect periodontal health or systemic inflammatory response (e.g., Diabetes Mellitus, immunological disorders).
• Current smokers or use of any tobacco products.
• Pregnancy or lactation.
• Use of systemic antibiotics, anti-inflammatory drugs, or immunosuppressive medications within the last 6 months.
• Having received any non-surgical or surgical periodontal treatment within the last 6 months.
• Known allergy or sensitivity to chlorhexidine or Morus nigra (blackberry) extracts.
• Patients using orthodontic appliances.