To evaluate the effectiveness of resveratrol mouthwash as adjunct to NSP treatment of periodontitis

• Measuring and comparing the efficacy of RV mouth wash in comparison with CHX and placebo mouth wash in improving the clinical periodontal parameters;
• Measuring the salivary cytokines (IL-6) before and after 4weeks of the use of RV mouth wash as adjunct to NSP treatment in comparison with other mouthwash by using enzyme-linked immunosorbent assay.
• Measuring the salivary RANKL before and after 4weeks of the use of RV mouth wash as adjunct to NSP treatment in comparison with other mouthwash by using enzyme-linked immunosorbent assay.
• Correlate the salivary cytokines IL-6 and salivary RANKL with clinical periodontal parameter and with each other.
• Evaluate the intervention by using Visual analog scale (VAS)- score-based questionnaire will be filled out by each participant at the end of the trial.

Inclusion Criteria:

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The inclusion criteria:

1. Participants need to be systemically healthy with age > 18 years old.
2. Not taking antibiotic and anti-inflammatory drugs in the last three months.
3. At least 20 teeth should be present
4. Should have unstable periodontitis (PPD ≥ 5 or BOP at 4mm pocket)

The exclusion criteria:

1. Patients wearing fixed prosthesis (crowns, bridges or orthodontic appliances)

2. Those with chronic disease, immunocompromised patients, pregnant, on contraceptives or lactating women.

3. Those currently using any mouthwash.

4. Those on antibiotic therapy and anti-inflammatory medications during the study and in the last 3 months before the study.

5. Those having a history of hypersensitivity to any product used in the present study.

6. Those who are smokers or alcoholics.

7. Those who refuse to participate in the trial.

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the supervisor will place the mouthwash in dark bottle with number so neither the examiner nor the patient will know the type of the mouthwash