Antihistamine for Prevention of HTR After Blood Primed CPB

Prophylactic Antihistamine for Prevention of Hypotensive Transfusion Reaction After Blood Primed Cardiopulmonary Bypass in Pediatric Cardiac Surgery: a Randomized-controlled Study

This study will be a randomized, double-blinded, placebo-controlled study conducted at a university hospital. Forty children undergoing elective repair of a congenital heart defect will be included. The patients will be randomly allocated (20 patients per group) to receive a single intravenous dose of combined chlorpheniramine or normal saline immediately after separation from CPB, before protamine administration.

Inclusion Criteria:

• Acyanotic congenital heart disease.
• Age :1 -7 years.
• Genre: both.

Exclusion Criteria:

• Redo patient.
• History of allergy to antihistamines.
• Bleeding disorders with INR > 1.5 and/or platelets < 50,000.
• Emergency procedure.