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The present study hypothesized that beyond its hemodynamic affects,retrograde autologus blood priming of cardiopulmonary bypass (RAP) has a positive impact on hemodynamics and pulmonary mechanics subjected to cardiac surgery.
This prospective randomized study analyzed the clinical records of 124 children subjected to cardiac surgery for congenital heart diseases with left to right shunt. They comprised 64 patients with RAP and 60 patients conventional cardiopulmonary bypass priming. The preoperative, intraoperative and postoperative data of the studied patients were reported.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Retrograde priming | Active Comparator | retrograde autologous Blood Priming of Cardiopulmonary Bypass (RAP) in young children subjected to cardiac surgery for congenital heart defects with left to right shunt associated with volume or pressure overload. |
|
| conventional priming | Active Comparator | conventional cardiopulmonary priming in young children subjected to cardiac surgery for congenital heart defects with left to right shunt associated with volume or pressure overload. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pediatric cardiac surgery | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of postoperative peak air way pressure between the studied groups | peak air way pressure (Paw) in cmH2O | 1 hour after surgery |
| Comparison of postoperative air way resistance between the studied groups | air way resistance (Raw) in cmH2O/L/sec. | 1 hour after surgery |
| Comparison of postoperative Plateau pressure between the studied groups | Plateau pressure in cm H2O | 1 hour after surgery |
| Comparison of postoperative Lung compliance between the studied groups | Lung compliance in L/cm H2O | 1 hour after surgery |
| Comparison of postoperative Tidal volume between the studied groups | Tidal volume in ml | 1 hour after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hamdy Singab, PhD | Ain shams university faculty of medicine | Principal Investigator |
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Pulmonary mechanics improvement in pediatric patients undergoing cardiac surgery with retrograde autologous priming
6 months
Pediatric cardiac surgeon
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| ID | Term |
|---|---|
| D006330 | Heart Defects, Congenital |
| ID | Term |
|---|---|
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
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Patients were included in the study if they had left to right shunt due to volume or pressure overload
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double-blind masking
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |