Effectiveness of Oleanolic Acid as Intracanal Medicament on Infectious/Inflammatory Contents in Teeth With Apical Periodontitis

Effectiveness of Oleanolic Acid as Intracanal Medicament on Infectious/Inflammatory Contents in Teeth With Apical Periodontitis

The objective of this study is to investigate "clinically" the effectiveness of Oleanolic acid based intracanal medicament compared to the commonly used intracanal medicaments (Calcium hydroxide and Ledermix) on the levels of bacteria in root canals and inflammatory cytokines in the periradicular tissues of teeth with apical periodontitis.

Inclusion Criteria:

1. Single rooted teeth with pulp necrosis and apical periodontitis.
2. The age ranges from 20 to 60 years.

Exclusion Criteria:

1. Patient receiving antibiotic treatment within the preceding 3 months.
2. Patient reporting systemic disease.
3. Teeth that can not be isolated with rubber dam.
4. Teeth with periodontal pockets deeper than 3 mm.