Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The objective of this study is to investigate "clinically" the effectiveness of Asiaticoside based intracanal medication compared to the commonly used intracanal medicaments (calcium hydroxide Ca(OH)2 and Ledermix) on the levels of bacteria and inflammatory cytokines in root canals and periradicular tissues of teeth with apical periodontitis.
This study investigate "clinically" the effectiveness of Asiaticoside based intracanal medication compared to the commonly used intracanal medicaments (calcium hydroxide Ca(OH)2 and Ledermix) on the levels of bacteria and inflammatory cytokines in root canals and periradicular tissues of teeth with apical periodontitis.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Calcium Hydroxide | Active Comparator | Intracanal medication |
|
| Leddermix | Active Comparator | Intracanal medication |
|
| Asiaticoside | Active Comparator | Intracanal medication |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Calcium Hydroxide Intracanal medication | Drug | Calcium Hydroxide Intracanal medication |
| |
| Measure | Description | Time Frame |
|---|---|---|
| counting the number of colonies forming units of bacterial cells Microbiology cell culturing (manual counting technique to the bacterial cells) [Time Frame: up to 7 months] | counting the number of colonies forming units of bacterial cells Microbiology cell culturing (manual counting technique to the bacterial cells) [Time Frame: up to 7 months] | up to 7 months |
| Measure | Description | Time Frame |
|---|---|---|
| using enzyme-linked immunosorbent assay (ELISA test) to measure the amount of Inflammatory Cytokines (TNF-α), (IL-1β) and (PG2) ELISA test to measure the amount of tumor necrotizing factor (TNF-α), interleukin 1β(IL-1β) and prostaglandin E2 (PG2) | using enzyme-linked immunosorbent assay (ELISA test) to measure the amount of Inflammatory Cytokines (TNF-α), (IL-1β) and (PG2) ELISA test to measure the amount of tumor necrotizing factor (TNF-α), interleukin 1β(IL-1β) and prostaglandin E2 (PG2) |
Not provided
Inclusion Criteria:
• Single-rooted with pulp necrosis and apical periodontitis.
Exclusion Criteria:
Receiving antibiotic treatment within the preceding 3 months.
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| salem alqahtani, master | Contact | 00201553553096 | Salemamq@gmail.com | |
| Ghada Abdelrazik | Contact | 00201003455012 | Salemamq@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Amany Bader, prof | Faculty of Dentistry Mansoura University | Study Director |
| Youssry Elhawary, prof | Faculty of Dentistry Mansoura University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mansoura university | Recruiting | Al Mansurah | Egypt |
Not provided
Not provided
Not provided
Not provided
Not provided
| Leddermix Intracanal medication |
| Drug |
Leddermix Intracanal medication |
|
| Asiaticoside Intracanal medication | Drug | Asiaticoside Intracanal medication |
|
|
| up to 25 weeks |
| ID | Term |
|---|---|
| D007249 | Inflammation |
| D003790 | Dental Pulp Necrosis |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003788 | Dental Pulp Diseases |
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
| D009336 | Necrosis |
Not provided
Not provided
| ID | Term |
|---|---|
| C526146 | Centella asiatica extract |
Not provided
Not provided
Not provided