Volunteers were divided into 2 groups: mulberry leaf extract capsule (DNJ 12mg) group and placebo group. They took the sample 3 times/day for 8 weeks. Complete blood count, Blood urea nitrogen (BUN), Creatinine, Aspartate transaminase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), Fasting plasma glucose, HbA1c, and adverse effects were evaluated before and after 4 and 8 weeks.

Volunteers were divided into 2 groups: mulberry leaf extract capsule (DNJ 12mg) group and placebo group. They took the sample 3 times/day for 8 weeks. Complete blood count, Blood urea nitrogen (BUN), Creatinine, Aspartate transaminase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), Fasting plasma glucose, HbA1c, and adverse effects were evaluated before and after 4 and 8 weeks. Satisfaction was assessed after 8 weeks.

Inclusion Criteria:

• Male or female age more than 18 years
• No Diabetis mellitus disease and no taking diabetes medication
• Blood sugar level less than 126 mg/dl and HbA1C less than 6.5
• Can using Thai language
• Willing to participate in the study

Exclusion Criteria:

• Allergic to mulberry extract
• Take mulberry extract in 2 weeks before participate in this study
• Take medications that have effect on blood sugar level such as steroid in 2 weeks before participate in this study
• Have uncontrolled disease
• Have AST, ALT, ALP more than 3 times of normal value, or estimated Glomerular Filtration Rate less than 30 ml/min/1.73 m2)
• Pregnancy or lactation