Effects of Adenoidectomy on Symptoms and IgE Levels in Children With AR

Effects of Adenoidectomy With or Without Tonsillectomy on Symptoms and Local IgE Levels in Children With Allergic Rhinitis

This study aims to evaluate the effects of conservative management versus surgical intervention (adenoidectomy alone or adenotonsillectomy) on symptoms and local IgE levels in children with allergic rhinitis (AR) accompanied with adenotonsillar hypertrophy. The primary objectives include the impact of conservative management and surgical interventions on AR symptoms and local IgE levels. The second outcomes include serum IgE levels, inflammatory cell profiles within the nasal mucosa, and postoperative complications.

Inclusion Criteria:

- 3-12 years

1. Children with physician-diagnosed allergic rhinitis and typical symptoms (nasal obstruction, watery rhinorrhea, paroxysmal sneezing);
2. Co-existing adenoidal and tonsillar hypertrophy meeting surgical indications;
3. No systemic or topical corticosteroids, leukotriene antagonists, or antihistamines within the past 3 months.

Exclusion Criteria:

1. Prior adenoidectomy, tonsillectomy, or radio-frequency ablation;
2. Nasal polyps, cystic fibrosis, primary ciliary dyskinesia, fungal rhinosinusitis, systemic vasculitis/granulomatosis, tumor, or immunodeficiency;
3. Endoscopic nasal surgery within 6 months or severe asthma precluding surgery;
4. Upper respiratory infection within 4 weeks;
5. Serious metabolic, cardiovascular, immune, neurologic, hematologic, gastrointestinal, cerebrovascular, or respiratory disease, or any condition judged by the investigator to interfere with outcome assessment or participant safety;
6. Currently enrolled or within 30 days of participation in another clinical trial.