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The purpose of this study is to assess the cardiopulmonary, hemodynamic, and symptom responses to acute bouts of varying intensity aerobic and resistance exercise in people with Spontaneous Coronary Artery Dissection (SCAD) and/or Fibromuscular Dysplasia (FMD).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aerobic and resistance exercise | Experimental | Patients with a history of Spontaneous Coronary Artery Dissection and/or Fibromuscular Dysplasia will undergo three exercise tests. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aerobic and resistance exercises | Behavioral | Subjects will undergo three exercise tests, each separated by at least 48 hours:
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| Measure | Description | Time Frame |
|---|---|---|
| Change in blood pressure in response to aerobic exercise | Systemic blood pressure will be measured at rest, at peak exercise, and for 5 minutes of recovery after exercise via finger photoplethysmography and reported as mmHg | Baseline, 5 minutes, 25 minutes, 50 minutes and 55 minutes |
| Dartmouth COOP Functional Assessment Chart score | The Dartmouth COOP Functional Assessment Charts are a set of patient-reported, pictorial tools used to measure physical, mental, and social functioning. The tool includes 9 questions that are rated on scores from 1-5, with higher scores indicating worse function. | Baseline |
| Duke Activity Index Status (DASI) score | The Duke Activity Status Index (DASI) is a self-administered questionnaire that measures a patient's functional capacity. It consists of 12 yes/no questions. Scores range from 0 to 58.2, with higher scores indicating better exercise capacity. | Baseline |
| International Physical Activity Questionnaire Short Form (IPAQ-SF) score | The International Physical Activity Questionnaire Short Form (IPAQ-SF) is a 7-item self-reported questionnaire where subjects report time spent being physically active in the last 7 days reported hours per day or minutes per day. | Baseline |
| Change in perceived exertion | Perceived exertion (breathlessness and leg fatigue) will be obtained using the Borg 0-10 scale. | Baseline, 25 minutes, and 50 minutes |
| Change in blood lactate concentration [La-]b | Blood lactate concentration [La-]b will be measured via analysis of a pinprick point-of-care lactate test (via the earlobe) at rest, during exercise, and at peak exercise. |
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Inclusion criteria:
Exclusion criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Armia R. Habil, MD | Contact | 904-953-0859 | habil.armia@mayo.edu |
| Name | Affiliation | Role |
|---|---|---|
| Elizabeth H. Dineen, DO | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic in Florida | Recruiting | Jacksonville | Florida | 32224 | United States |
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| Label | URL |
|---|---|
| Mayo Clinic Clinical Trials | View source |
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| ID | Term |
|---|---|
| D005352 | Fibromuscular Dysplasia |
| C565153 | Coronary Artery Dissection, Spontaneous |
| ID | Term |
|---|---|
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| Baseline, 25 minutes, and 50 minutes |