Immun4Cure Cohort of Autoimmune Diseases

Prospective Cohort Study of Clinical and Biological Data in Patients With Autoimmune Diseases (Immun4Cure Cohort)

This prospective cohort study aims to constitute a 500-participant database and biobank including 450 adults with systemic autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis) and 50 healthy controls.

The Immun4Cure Cohort is a monocentric prospective cohort conducted at Montpellier University Hospital. Autoimmune diseases (AIDs) are complex, heterogeneous conditions involving dysregulation of innate and adaptive immunity, chronic inflammation, and irreversible tissue damage. The three targeted diseases-rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc represent major public-health challenges due to their severity, treatment burden, and impact on quality of life.

The study integrates standardized longitudinal clinical follow-up over 5 years, deep phenotyping, multi-omic analyses (genomics, transcriptomics, proteomics, metabolomics, immunophenotyping), environmental exposure assessment, and biological sample collection (blood, serum, plasma, PBMCs, urine, stool, saliva, optional tissue biopsies).

Healthy subjects undergo baseline and 12-month evaluations to establish reference immune, metabolic, and environmental signatures. This cohort will serve as a foundational research platform for translational studies and ancillary projects on autoimmune diseases.

Inclusion Criteria Participants:

Group 1: RA

• Adults ≥18 years
• Patient followed as part of their MAI in one of the departments participating in the study at UHM
• Confirmed diagnosis according to international criteria :ACR/EULAR 2010

Group 2: LES

• Adults ≥18 years
• Patient followed as part of their MAI in one of the departments participating in the study at UHM
• Confirmed diagnosis according to international criteria :ACR/EULAR 2019

Group 3: SSc

• Adults ≥18 years
• Patient followed as part of their MAI in one of the departments participating in the study at UHM
• Confirmed diagnosis according to international criteria :ACR/EULAR 2013

Group 4: Healthy Controls

• Adults ≥18 years
• No symptoms of autoimmune disease
• No first-degree family history of autoimmune disease

Exclusion Criteria (all groupes):

• Patients who have refused or are unable to give informed consent
• Inability to follow the subject during the study period
• Participation in another interventional study that includes an exclusion period that is still ongoing
• Pregnant women
• Not affiliated with a social security scheme
• Patients without a national insurance number
• Persons under judicial protection, guardianship or trusteeship
• Persons deprived of their liberty