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| ID | Type | Description | Link |
|---|---|---|---|
| 05570-6/2023 | Other Identifier | National Public Health Centre Institutional Committee of Science and Research Ethics Hungary |
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Objectives: Systemic autoimmune diseases are chronic diseases characterized by chronic inflammation, vasculopathy, and autoimmune phenomena. Several organ involvements are typical, including the central nervous system. Formerly published investigations emphasize a mild cognitive impairment affecting attention, memory, and complicated solution tasks. However, these symptoms significantly impact patients' routines and quality of life. The study examined the associations between cognitive impairment and clinical parameters regarding systemic autoimmune diseases.
Methods: General clinical data, some serum biomarkers including CCl-18, YKL-40, COMP, VEGF, Galectin-3, and Pentraxin as well as results of functional, quality of life, and neuropsychological measures, the Mini-Mental State Examination (MMSE), the Digit Span Forward-Backward, the Trail making A, B and the Digit Symbol tests all were administered.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diffuse cutaneous Systemic sclerosis | Physical examination, routine blood, immunoserology, and special biomarker laboratory examination. General health, functional, and quality of life questionnaires, and neuropsychological measures are administered. | ||
| Limited cutaneous Systemic sclerosis | Physical examination, routine blood, immunoserology, and special biomarker laboratory examination. General health, functional, and quality of life questionnaires, and neuropsychological measures are administered. | ||
| Primary Raynaud's | Physical examination, routine blood, immunoserology, and special biomarker laboratory examination. General health, functional, and quality of life questionnaires, and neuropsychological measures are administered. | ||
| Healthy | Physical examination, routine blood, immunoserology, and special biomarker laboratory examination. General health, functional, and quality of life questionnaires, and neuropsychological measures are administered. | ||
| Rheumatoid arthritis | Physical examination, routine blood, immunoserology, and special biomarker laboratory examination. General health, functional, and quality of life questionnaires, and neuropsychological measures are administered. | ||
| Inflammatory myopathies |
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| Measure | Description | Time Frame |
|---|---|---|
| Mini-mental State Examination | Complex Cognitive measure | 12 months |
| The Functional Assessment of Chronic Illness Therapy F | health-related quality of life measure | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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Consecutive patients were enrolled into the study originating from the Rheumatology and Immunology Department, Medical School, University of Pécs.
Control healthy groups including consecutive sex and age-matched healthy individuals are invited to participate.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Pécs, Department of Rheumatology and Immunology | Pécs | 7632 | Hungary |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32293528 | Background | Olah C, Schwartz N, Denton C, Kardos Z, Putterman C, Szekanecz Z. Cognitive dysfunction in autoimmune rheumatic diseases. Arthritis Res Ther. 2020 Apr 15;22(1):78. doi: 10.1186/s13075-020-02180-5. | |
| 40757427 | Derived | Krampek L, Kiss F, Farkas N, Faludi R, Nagy G, Szabo A, Czirjak L, Varju C. Risk factors of cognitive function impairment in patients with systemic sclerosis. Clin Exp Rheumatol. 2025 Aug;43(8):1481-1491. doi: 10.55563/clinexprheumatol/isx6h8. Epub 2025 Aug 1. |
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Data are not publicly available due to ethical issues.
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| ID | Term |
|---|---|
| D012595 | Scleroderma, Systemic |
| D008180 | Lupus Erythematosus, Systemic |
| D009220 | Myositis |
| D001172 | Arthritis, Rheumatoid |
| ID | Term |
|---|---|
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D012871 | Skin Diseases |
| D001327 | Autoimmune Diseases |
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Investigations of serum samples for biomarkers
Physical examination, routine blood, immunoserology, and special biomarker laboratory examination. General health, functional, and quality of life questionnaires, and neuropsychological measures are administered. |
| Systemic lupus erythematosus | Physical examination, routine blood, immunoserology, and special biomarker laboratory examination. General health, functional, and quality of life questionnaires, and neuropsychological measures are administered. |
| D007154 | Immune System Diseases |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D012216 | Rheumatic Diseases |