The Role of Urinary RhoA, NGF, and BDNF Levels in Overactive Bladder and Vitamin D Deficiency

The Role of Urinary RhoA, NGF, and BDNF Levels in Diagnosis and Follow-up in Children With Overactive Bladder and Vitamin D Deficiency.

The primary aim of this study is to evaluate the role of three specific urinary proteins-RhoA, Nerve Growth Factor (NGF), and Brain-Derived Neurotrophic Factor (BDNF)-as potential biomarkers for the diagnosis and follow-up of children aged 4-18 diagnosed with Overactive Bladder (OAB) and Vitamin D deficiency.

Inclusion Criteria:

• Children aged 4-18 years presenting with active OAB symptoms (frequency, urgency)

Exclusion Criteria:

• Neurological diseases
• Malignancy
• Active urinary tract infections
• Anatomical bladder anomalies
• History of prior OAB treatment/urological surgery.