Treatment with semaglutide slows down gastric emptying , food remains in the stomach for a longer period of time. This slowing has important implications for anesthesia management. At present, we do not know the optimal duration for discontinuing this medication before surgery and anesthesia to ensure an empty stomach.

This is an observational research project, conducted exclusively at the Geneva University Hospitals (HUG). To answer the research question, participation of 38 individuals will be required. The duration of participation for each person is 7 days.

To recruit the necessary number of participants, approximately 1.5 years will be needed.

This project is being carried out in accordance with Swiss legal requirements and recognized international guidelines. The competent ethics committee has reviewed and approved this project.

The project will last 7 day during which the participants will need to come 3 times at the hospital to make gastric ultrasounds. On these days the participants will be asked to have a breakfast between 7 and 8 am including a minimum of bread and/or cereals and/or proteins. After that the participants will be asked to fast for 6 hours for solide food and 2 hours for liquids. If the participants smokes, they must for 12h before the exam.

At 2Pm an anesthesiologist will welcome the participant to make the exam at the hospital to evaluate the gastric volume after what the participants will be able to get a small collation and go back home.

Inclusion Criteria:

• Female/ Male of 18 years old or more
• With Type 2 Diabetes
• Treated with GLP 1 analog for more than 3 months
• Signed consent
• ASA between I and IV

Exclusion Criteria:

• Insuline treatment
• Gastro intestinal motility disorders
• Past gastric surgery
• Hiatal hernia
• Recent trauma
• Inability to be lay down for the exam
• Inability to follow the instructions for the exam (language, dementia)
• BMI > 40
• Inability to stop smoking 12h before the measures

Diabetic patients treated by GLP-1 analog