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The goal of this interventional clinical trial is to investigate the effects of breathing exercises added to balance training on cognitive function in individuals aged 65 years and older.
The main questions it aims to answer are:
Do breathing exercises affect cognition? Do different breathing exercises affect cognition in different ways?
Researchers will administer two different breathing protocols and evaluate cognition before and after each protocol.
Participants will take part in an 8-week program consisting of sessions that include 30 minutes of balance-based exercises and 15 minutes of breathing exercises. Sessions will be held twice weekly under the supervision of a physical therapist.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Inspiratory Muscle Training | Experimental |
| |
| Breathing Exercises | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Balance Training Program | Other | A structured balance-based exercise program (30 minutes per session) designed to reduce fall risk and improve functional performance. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Montreal Cognitive Assessment (MoCA) | The Montreal Cognitive Assessment (MoCA) is used to assess global cognitive function. The total score ranges from 0 to 30, with higher scores indicating better cognitive performance. | From enrollment to the end of intervention at 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Spirometry Parameters (FEV1, FVC, FEV1/FVC Ratio) | Spirometry will be used to assess pulmonary function, including forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio. Higher values indicate better pulmonary function. | From enrollment to the end of intervention at 8 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Deema Almurad | Contact | 00905010492000 | deemaalmurad@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Müzeyyen Keçeli Aile Sağlığı Merkezi | Recruiting | Istanbul | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35173204 | Background | Johannknecht M, Kayser C. The influence of the respiratory cycle on reaction times in sensory-cognitive paradigms. Sci Rep. 2022 Feb 16;12(1):2586. doi: 10.1038/s41598-022-06364-8. | |
| 38671954 | Background | Vanutelli ME, Grigis C, Lucchiari C. Breathing Right... or Left! The Effects of Unilateral Nostril Breathing on Psychological and Cognitive Wellbeing: A Pilot Study. Brain Sci. 2024 Mar 23;14(4):302. doi: 10.3390/brainsci14040302. |
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| Inspiratory Muscle Training | Other | Training performed using a threshold device to strengthen inspiratory muscles for 15 minutes with intensity set individually and progressively adjusted. |
|
| Breathing Exercise Program | Other | Breathing exercises aimed at improving lung function and respiratory health, including diaphragmatic breathing and pursed-lip breathing. Exercises will be performed for 15 minutes |
|
| Maximal Inspiratory and Expiratory Pressures (MIP/MEP) |
Respiratory muscle strength will be assessed using maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) measurements. Higher values indicate greater respiratory muscle strength. |
| From enrollment to the end of intervention at 8 weeks |
| 40330797 | Background | Song F, Ding K, Sun W, Huang Q, Jiang R, Xiang H, Sun M. Effects of 12 weeks of Head-Down Strong Abdominal Breathing Training on Gait and Cognitive Function in Patients with Chronic Obstructive Pulmonary Disease. Int J Chron Obstruct Pulmon Dis. 2025 May 1;20:1347-1359. doi: 10.2147/COPD.S514766. eCollection 2025. |
| 27927961 | Background | Zelano C, Jiang H, Zhou G, Arora N, Schuele S, Rosenow J, Gottfried JA. Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function. J Neurosci. 2016 Dec 7;36(49):12448-12467. doi: 10.1523/JNEUROSCI.2586-16.2016. |
| 37271298 | Background | Braendholt M, Kluger DS, Varga S, Heck DH, Gross J, Allen MG. Breathing in waves: Understanding respiratory-brain coupling as a gradient of predictive oscillations. Neurosci Biobehav Rev. 2023 Sep;152:105262. doi: 10.1016/j.neubiorev.2023.105262. Epub 2023 Jun 3. |