Effect of Nicotine Gingival Fibroblast Intoxication on the Response of Periodontal Treatment

Effect of Nicotine Gingival Fibroblast Intoxication on the Response of Periodontal Treatment, in Conventional and Non Smokers: a Controlled Clinical Trial

Impact of nicotine gingival intoxication on the clinical outcomes after periodontitis non surgical treatment

In patients suffured of periodontitis, to evaluate the effect of nicotine gingival tissue intoxication and others smoking indicators on the severity of periodontitis and outcomes after nonsurgical periodontal treatment."

Inclusion Criteria: patient suffured of periodontitis, smoker and non-smoker

• patient suffured of periodontitis
• smoker and non-smoker
• presence of a minimum of 6 teeth at each arch
• minimum of 6 teeth with pocket depth of 5 mm
• signed informed consent

Exclusion Criteria:

• diabetes,
• connective tissue disease
• pregnancy
• radiotherapy
• chemotherapy
• psychological disease
• previous periodontal therapy
• antibiotics intake