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Impact of nicotine gingival intoxication on the clinical outcomes after periodontitis non surgical treatment
In patients suffured of periodontitis, to evaluate the effect of nicotine gingival tissue intoxication and others smoking indicators on the severity of periodontitis and outcomes after nonsurgical periodontal treatment."
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| conventionnal smoker group | Active Comparator | patient who smokes conventionnal cigarette |
|
| Non smoker group | Placebo Comparator | patient who don't smoke cigarette |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| periodontal non-surgical treatment | Procedure | The procedure will consist of non-surgical periodontal treatment (NSPT), consisting of the removal of supra- and subgingival plaque using ultrasonic instruments. Prior to the NSPT, all unstimulated saliva will be collected using Eppendorf. During local anesthesia for the NSPT, a gingival tissue biopsy will be performed using a 2mm wide and 4mm deep punch in the maxillary retromolar area behind the last tooth in the arch. |
| Measure | Description | Time Frame |
|---|---|---|
| nicotine/cotinine in gum (ng/ml) | concentration cotinine and nicotine (ng/ml) | the day of the periodontal non surgical treatment |
| Measure | Description | Time Frame |
|---|---|---|
| PD (mm) | periodontal pocket depth (mm) Secondary outcomes: percentage of sites with PD ≥ 6 mm, furcation involvement, mobility assessment, bleeding on probing score (BoP), plaque score (PI). | baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after |
| % PD ≥ 6 mm (%) |
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Inclusion Criteria: patient suffured of periodontitis, smoker and non-smoker
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Departement of periodontology, buccal surgery and implantology- Uliège, Belgium | Liège | Liege | 4000 | Belgium |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D016540 | Smoking Cessation |
| D014029 | Tobacco Use Disorder |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D015438 | Health Behavior |
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comparison between smokers and non-smokers
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|
percentage of sites with PD ≥ 6 mm |
| baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after |
| FTND score ( 0 to 9) | Fagerström test for nictnie dependance ( scale from 0 to 9) 0-2: Very low dependence 3-4: Low dependence 5: Medium dependence 6-7: High dependence 8-10: Very high dependence | the day of periodontal non-surgical treatment |
| PY (number/year) | number of packet of cigarettes smoked per year | the day of periodontal non-surgical treatment |
| NCC (0 to 100) | number of cigartes consummed per day
| the day of periodontal non-surgical treatment |
| Furc (I,II or III) | furcation involvement | baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after |
| periodontal ouctomes | tooth mobility ( 1,2 or 3) | baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after |
| BOP (%) | bleeding on probing | baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after |
| PI (%) | plaque score | baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after |
| D001519 |
| Behavior |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |