Not provided
Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 01/2025/BVGĐ-HĐĐĐ | Other Identifier | Da Nang Family General Hospital |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Carpal Tunnel Syndrome (CTS) is the most common peripheral nerve compression disorder in adults. Although electromyography (EMG) is the current gold standard for diagnosis, it is invasive, time-consuming, and may yield false-negative results. Ultrasound elastography, including shear wave elastography and strain elastography, enables non-invasive assessment of median nerve stiffness, reflecting fibrosis and edema. However, data on the combined use of elastography and microvascular imaging in CTS are still limited in Vietnam. This study aims to evaluate the value of advanced ultrasound techniques in diagnosing CTS and grading disease severity, as well as their correlation with clinical symptoms and EMG findings
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ultrasound Elastography | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic Accuracy of Shear Wave Elastography for Carpal Tunnel Syndrome | Sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) of shear wave elastography values (kPa) for diagnosing carpal tunnel syndrome using electrodiagnostic testing as the reference standard. | At baseline (data collected at the time of retinal examination during the study period from April 2025 to February 2026) |
| Diagnostic Accuracy of Strain Elastography (SE) for Carpal Tunnel Syndrome | Sensitivity, specificity, and AUC of strain elastography grading for diagnosing carpal tunnel syndrome using electrodiagnostic testing as the reference standard. | At baseline (data collected at the time of retinal examination during the study period from April 2025 to February 2026) |
| Diagnostic Accuracy of Median Nerve Cross-Sectional Area (CSA) for Carpal Tunnel Syndrome | Sensitivity, specificity, and AUC of median nerve cross-sectional area (mm²) measured at the carpal tunnel inlet for diagnosing carpal tunnel syndrome using electrodiagnostic testing as the reference standard. | At baseline (data collected at the time of retinal examination during the study period from April 2025 to February 2026) |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation | Correlation coefficients (Pearson/Spearman) between ultrasound parameters (Stiffness, CSA) and:
| At baseline (data collected at the time of retinal examination during the study period from April 2025 to February 2026) |
Not provided
Inclusion Criteria:
Inclusion Criteria (Case Group)
Inclusion Criteria (Control Group)
Exclusion Criteria:
Not provided
Not provided
Not provided
Clinical suspicion of CTS with at least one sign: numbness/pain in the median nerve distribution (digits 1, 2, 3, and lateral 4), nocturnal symptoms, or positive provocative tests (Tinel, Phalen, Durkan).
Confirmed diagnosis of CTS via Electrodiagnostic studies (NCS/EMG) based on American Academy of Neurology (AAN) and AANEM criteria.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Nguyen Do Ngoc Linh, MD | Da Nang Family General Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Da Nang family general Hospital | Da Nang | 55000 | Vietnam |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Result | 1. El-Shewi, Islam El-Hefnawi et al. (2024), "Role of conventional ultrasound and shear wave elastography of median nerve in diagnosis and differentiation of carpal tunnel syndrome severity in correlation with electrodiagnostic studies", Egyptian Journal of Radiology and Nuclear Medicine. 55(1), tr. 53. 2. Joshi, Aditya et al. (2022), "Carpal tunnel syndrome: pathophysiology and comprehensive guidelines for clinical evaluation and treatment", Cureus. 14(7). 3. Schrier, Verena JMM et al. (2020), "Shear wave elastography of the median nerve: a mechanical study", Muscle & Nerve. 61(6), tr. 826-833. 4. Sernik, Renato Antonio et al. (2023), "Shear wave elastography is a valuable tool for diagnosing and grading carpal tunnel syndrome", Skeletal radiology. 52(1), tr. 67-72. 5. Wu, Han et al. (2022), "Ultrasound and elastography role in pre-and post-operative evaluation of median neuropathy in patients with carpal tunnel syndrome", Frontiers in Neurology. 13, tr. 1079737. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D002349 | Carpal Tunnel Syndrome |
| ID | Term |
|---|---|
| D020423 | Median Neuropathy |
| D020422 | Mononeuropathies |
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
| Cut-off Values |
Optimal threshold values for SWE (kPa) and CSA (mm2) to distinguish CTS from controls and to classify severity. |
| At baseline (data collected at the time of retinal examination during the study period from April 2025 to February 2026) |
| D009422 | Nervous System Diseases |
| D009408 | Nerve Compression Syndromes |
| D012090 | Cumulative Trauma Disorders |
| D013180 | Sprains and Strains |
| D014947 | Wounds and Injuries |