Serious Game Rehabilitation and Brain Plasticity in MS

Brain Reorganization After Serious Game -Based Cognitive Rehabilitation in Multiple Sclerosis

This prospective, interventional, longitudinal, multicentre study aims to evaluate the impact of the "Serious game", an innovative cognitive remediation tool on brain reorganization in Multiple sclerosis patients, using functional Magnetic resonance imaging (MRI). The serious game is a tool combining the motivational mechanisms of video games with cognitive remediation techniques.

Inclusion Criteria:

• People with relapsing-remitting or progressive MS defined according to the 2010 revised McDonald criteria [56]
• Cognitive complaints and deficits in at least one score on the initial neuropsychological examination (<5th percentile of the reference group)
• Aged between ≥ 18 and ≤ 65 years
• No defined relapse for at least 6 weeks
• At least 4 weeks since a corticosteroid bolus
• Patient with an internet connection
• Patient covered by social security
• Signed informed consent

Exclusion Criteria:

• Claustrophobia preventing MRI;
• Contraindication to MRI;
• Wearing fixed dental braces;
• Unable to receive oral and written information;
• Unable to use the software (due in particular to motor and/or sensory difficulties);
• Neurological or psychiatric comorbidity, other than MS and anxiety-depression syndrome,
• Patient with severe anxiety-depression syndrome (BDI-FS > 10),
• Pregnant or breastfeeding women
• Taking neuroleptic treatment
• Person under guardianship or curatorship
• Person deprived of liberty