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| Name | Class |
|---|---|
| Jinnah Sindh Medical University | OTHER |
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This study looked at two different medicines used during local anesthesia to control pain after surgery. Investigators compared bupivacaine alone with bupivacaine mixed with tramadol. Both medicines are commonly used to numb the surgical area and reduce pain.
The investigators included 100 adult patients who had minor surgeries under local anesthesia. Half received only bupivacaine, and the other half received bupivacaine combined with tramadol. After surgery, patients were asked to rate their pain at 4, 8, and 24 hours.
The results showed that patients who received bupivacaine with tramadol felt less pain, especially at 24 hours after surgery, compared to those who received bupivacaine alone.
In simple words:
Adding tramadol to bupivacaine helps reduce pain better than bupivacaine alone.
This method may help patients recover faster, feel more comfortable, and need fewer pain medicines after surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Use of Bupivacaine alone for treating postoperative pain | Active Comparator |
| |
| Use of Bupivacaine and Tramadol together for treating postoperative pain | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tramadol | Drug | A single dose of 1 mg/kg tramadol at the surgical site |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mean postoperative pain score | Mean postoperative pain score using the visual analog scale at 4,8 and 24 hours postoperatively. Visual Analog Scale (VAS) is a 10-cm horizontal line ranging from 0 (no pain) to 10 (worst imaginable pain). Patients will mark the point representing their pain intensity. Scores will be recorded at predetermined postoperative intervals. | Patients were monitored for 24 hours immediately following the completion of the surgical procedure |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jinnah postgraduate medical university | Karachi | Sindh | 75510 | Pakistan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | Malik AI, Sheikh IA, Qasmi SA, Adnan A. Comparison of tramadol with bupivacaine as local anaesthetic in postoperative pain control. Journal of Surgery Pakistan (International). 2011 Jan;16(1):10-3. | ||
| 18940114 | Background | Khan S, Memon MI. Comparison of caudal bupivacaine and bupivacaine-tramadol for postoperative analgesia in children with hypospadias repair. J Coll Physicians Surg Pak. 2008 Oct;18(10):601-4. doi: 10.2008/JCPSP.601604. | |
| 32660546 |
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Individual Participant Data (IPD) will not be shared because the dataset contains potentially identifiable clinical information collected from a relatively small study population. Participants did not provide explicit consent for public data sharing beyond the purposes of this study. In addition, the data are being used solely for predefined analyses, and there are no current plans for secondary analyses requiring external data access. Aggregate results will be published to ensure transparency while maintaining participant confidentiality.
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D014147 | Tramadol |
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D003511 | Cyclohexanols |
| D000441 | Hexanols |
| D005233 | Fatty Alcohols |
| D000438 | Alcohols |
| D009930 |
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| Bupivacaine | Drug | Single dose 0.5 ml/kg of 0.25% Bupivacaine at surgical site |
|
| Background |
| Passavanti MB, Piccinno G, Alfieri A, Di Franco S, Sansone P, Mangoni G, Pota V, Aurilio C, Pace MC, Fiore M. Local infiltration of tramadol as an effective strategy to reduce post-operative pain: a systematic review protocol and meta-analysis. Syst Rev. 2020 Jul 13;9(1):157. doi: 10.1186/s13643-020-01419-1. |
| 26213198 | Background | Kelley BP, Shauver MJ, Chung KC. Management of Acute Postoperative Pain in Hand Surgery: A Systematic Review. J Hand Surg Am. 2015 Aug;40(8):1610-9, 1619.e1. doi: 10.1016/j.jhsa.2015.05.024. |
| Background | Obsa MS, Andebirku AA, Gemechu AD, Haile KE. Effectiveness of tramadol with bupivacaine versus bupivacaine alone on postoperative analgesia at Wolaita Sodo, southern Ethiopia: Observational Cohort Study. 2021 |
| 26827847 | Background | Chou R, Gordon DB, de Leon-Casasola OA, Rosenberg JM, Bickler S, Brennan T, Carter T, Cassidy CL, Chittenden EH, Degenhardt E, Griffith S, Manworren R, McCarberg B, Montgomery R, Murphy J, Perkal MF, Suresh S, Sluka K, Strassels S, Thirlby R, Viscusi E, Walco GA, Warner L, Weisman SJ, Wu CL. Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain. 2016 Feb;17(2):131-57. doi: 10.1016/j.jpain.2015.12.008. |
| 32076833 | Background | Jenkins NW, Parrish JM, Mayo BC, Hrynewycz NM, Brundage TS, Mogilevsky FA, Yoo JS, Singh K. The identification of risk factors for increased postoperative pain following minimally invasive transforaminal lumbar interbody fusion. Eur Spine J. 2020 Jun;29(6):1304-1310. doi: 10.1007/s00586-020-06344-4. Epub 2020 Feb 19. |
| 29026331 | Background | Gan TJ. Poorly controlled postoperative pain: prevalence, consequences, and prevention. J Pain Res. 2017 Sep 25;10:2287-2298. doi: 10.2147/JPR.S144066. eCollection 2017. |
| 26893579 | Background | Kuusniemi K, Poyhia R. Present-day challenges and future solutions in postoperative pain management: results from PainForum 2014. J Pain Res. 2016 Feb 3;9:25-36. doi: 10.2147/JPR.S92502. eCollection 2016. |
| 28867907 | Background | Labrum JT 4th, Ilyas AM. Preemptive Analgesia in Thumb Basal Joint Arthroplasty: Immediate Postoperative Pain with Preincision versus Postincision Local Anesthesia. J Hand Microsurg. 2017 Aug;9(2):80-83. doi: 10.1055/s-0037-1603734. Epub 2017 Jun 5. |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| Organic Chemicals |
| D004123 | Dimethylamines |
| D008744 | Methylamines |
| D000588 | Amines |
| D008055 | Lipids |
| D000813 | Anilides |
| D000577 | Amides |
| D000814 | Aniline Compounds |