Effect of Topical Insulin on Healing Rate of Pemphigus Lesions

Effect of Topical Insulin on Healing Rate of Pemphigus Lesions

This study investigates the efficacy of topical insulin in promoting healing of pemphigus vulgaris erosions. Twenty patients with pemphigus vulgaris were enrolled, each contributing three comparable lesions randomly allocated to receive long-acting insulin (insulin glargine), short-acting insulin (regular insulin), or normal saline control. Treatments were applied topically twice daily for 14 days or until complete healing.

Inclusion Criteria:

• Confirmed diagnosis of pemphigus vulgaris by clinical and histopathological criteria
• Presence of erosions and/or ulcers on skin and/or mucous membranes
• At least three lesions of comparable location, size, depth, and healing stage

Exclusion Criteria:

• Lesions with clinical signs of secondary infection (purulence, surrounding erythema, fever)
• Uncontrolled general condition significantly affecting wound healing (e.g., hypoalbuminemia)
• Known allergy to insulin