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The main aim of the study is to determine the effect of transdermal application of insulin therapy by phonophoresis in wound healing in diabetic patients the main question of the study: is insulin phonophoresis is effective in accelerating healing in patients with diabetes mellites? 40 patients will be randomly assigned to two groups group A will receive insulin phonophoresis plus hyper polarized laser therapy and standard wound cleaning and dressing three times weekly over four weeks.
Group B will receive hyper polarized laser therapy and standard wound cleaning and dressing three times weekly over four weeks.
DIMST scale ( as an acronym from the initial domains of depth, maceration, inflammation/infection, size, tissue type of the wound bed, type of wound edge, and tunneling/undermining) will be used for assessment.
MANOVA will be used for statistical analysis between group comparison
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Experimental | subjects will receive Phonophoresis Insulin Therapy, hyperpolarized light therapy and Standard wound cleaning and dressing. |
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| Group B | Sham Comparator | subjects will receive hyperpolarized light therapy and Standard wound cleaning and dressing |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Insulin therapy phonophoresis | Other | Insulin therapy phonophoresis is the use of ultrasound to deliver drugs through patients skin, Insulin therapy will be used to determine its effect on wound healing in patients with chronic diabetes mellites because in addition to its systemic impact, numerous reports suggest that applying insulin topically causes localized effects. Many trials and case reports have been released reporting positive effects of topical insulin for many diseases such as dermatological compromises, ophthalmological diseases and others |
| Measure | Description | Time Frame |
|---|---|---|
| DMIST scale which is a valid and reliable scale for measuring depth, maceration, inflammation/infection, size, tissue type of the wound bed, type of wound edge, and tunneling/undermining. | Zero will be the minimum score and 98 was the maximum, with a greater number denoting a more severe injury and a zero signaling full recovery | before first session and at the end of the treatment program (four weeks) |
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Inclusion Criteria:
Exclusion Criteria:
patients will be excluded if they have any pathological condition like limb infection, local or proximate malignancy, and anti-coagulated patients.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| amira saad Mohamed, Master degree | Contact | 02-01092128481 | amira.saad.mm@gmail.com |
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| Label | URL |
|---|---|
| EFFECT OF TRANSDERMAL INSULIN DELIVERY BY LOW INTENSITY ULTRASOUND IN HEALING OF CHRONIC LOWER LIMB VENOUS ULCER | View source |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D001458 | Bandages |
| ID | Term |
|---|---|
| D004864 | Equipment and Supplies |
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| Hyperpolarized light therapy and Standard wound cleaning and dressing. | Other | Hyperpolarized light therapy safely accelerates wound healing by stimulating blood circulation, reducing inflammation and relieving muscle spasms. |
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