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This study aims to improve the quality of 12-lead ECG recordings taken during a cardiac MRI scan. The ECG is important for monitoring the heart's rhythm and for properly timing MRI image acquisition.
During MRI scans, the magnetic field can distort ECG signals, making it more difficult to accurately monitor the heart. By improving ECG signal quality during MRI, we hope to enhance patient safety, improve monitoring for patients with implanted heart devices, and support MRI-guided procedures.
ECG signals acquired within the MRI environment are prone to distortion due to the influence of the static magnetic field (SMF), time-varying gradients (i.e. gradient-induced voltages (GIVs)), and radio frequency (RF) pulses. In particular, the MHD effects, predominantly resulting from the pulsatile aortic electrically conductive blood flow within the magnetic field, produce ECG distortions that potentially obscure important ECG-features, like acute changes in the ST-segment and T-wave.
These distortions not only hinder accurate ECG interpretation but may also compromise image quality due to erroneous cardiac triggering. Furthermore, time-varying magnetic field gradients induce gradient-induced voltages (GIVs) during active scanning sequences, producing characteristic ECG artifacts that further challenge signal reliability within the MRI environment.
Recently, a first CE-marked, commercially available MRI-compatible 12-lead ECG system (MiRTLE Medical, North Andover, MA, USA) was introduced, enabling ECG acquisition during MRI scanning using conventional standard 12-lead electrode positions during MRI scanning. Though, However, the ECG signals remain susceptible to magnetohydrodynamic (MHD) effects and gradient-induced voltages (GIVs), limiting their reliability and interpretability.
This study, therefore, aims to systematically characterize ECG distortion patterns and develop validated noise-reduction strategies. To this end, 12-lead ECGs will be recorded from patients undergoing routine CMR to establish a database encompassing diverse pulse sequences and clinical conditions.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MR-compatible 12-lead ECG recording system | Device | Continuous 12-lead ECG recordings will be measured during cardiac MRI scans, using the MiRTLE Medical system. In addition, a reference clean ECGs will be measured outside the MRI environment. |
| Measure | Description | Time Frame |
|---|---|---|
| ECG signal quality during cardiac MRI | ECG signal quality can be measured by the root-mean-squared error (RMSE) and cross-correlation between the reference and in-bore MRI recordings. ECG signal quality is compromised by the magnetohydrodynamic (MHD) effect and gradient-induced voltages (GIVs). Both contributions will be quantified separately, and dedicated mitigation strategies will be developed and evaluated to reduce their impact on ECG quality. | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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Any patient referred for CMR can qualify for this study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Professor dr. Götte | Contact | 4039448697 | marco.gotte@ucalgary.ca |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | MiRTLE Medical L. MiRTLE Medical Product 2025. https://mirtlemed.com/product (accessed March 21, 2025). | ||
| 5902099 | Background | Mason RE, Likar I. A new system of multiple-lead exercise electrocardiography. Am Heart J. 1966 Feb;71(2):196-205. doi: 10.1016/0002-8703(66)90182-7. No abstract available. | |
| 29527149 |
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If required, only fully anonymized ECG recordings and MRI scans will be shared. All directly and indirectly identifiable information will be removed prior to data sharing, and no personal data will be transferred to external parties.
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| Background |
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| 40912881 | Background | Si D, Littlewood SJ, Crabb MG, Phair A, Prieto C, Botnar RM. Cardiovascular magnetic resonance imaging: Principles and advanced techniques. Prog Nucl Magn Reson Spectrosc. 2025 Aug-Oct;148-149:101561. doi: 10.1016/j.pnmrs.2025.101561. Epub 2025 Feb 24. |
| 34331487 | Background | Guo R, Weingartner S, Siuryte P, T Stoeck C, Fuetterer M, E Campbell-Washburn A, Suinesiaputra A, Jerosch-Herold M, Nezafat R. Emerging Techniques in Cardiac Magnetic Resonance Imaging. J Magn Reson Imaging. 2022 Apr;55(4):1043-1059. doi: 10.1002/jmri.27848. Epub 2021 Jul 31. |