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| Name | Class |
|---|---|
| H.S.P.I. s.p.a. | UNKNOWN |
| Catholic University of the Sacred Heart | OTHER |
| Fondazione Don Carlo Gnocchi ETS | OTHER |
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The main objective of the TERSICORE project is the development of a new advanced set of exergames in the Metaverse that can be used in all clinical and home rehabilitation devices to improve the cognitive therapy of neurological patients by exploiting the potential of social rehabilitation. Five specific exargames will be developed: a) Cooking therapy (Coordinating in a kitchen to complete a dish through shared activities); b) Escape Room (Exiting a simulated room by solving problems and logic puzzles); c) Nostalgia Bits (Sharing personal reminiscence narratives within simulated spaces); d) NeuroTeam (Mindfulness); and e) Truman Show Exploration of an urban space and role-playing.
All exargames will be validated on a small population of neurological patients according to cognitive profile.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Arm End-Users | Experimental | Acceptability evaluation of TERSICORE digital platform |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive rehabilitation with TERSICORE digital platform | Device | Small groups of end-users will participate in various cognitive tasks carried out in common virtual environments (Metaverse). |
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility: Acceptability of Intervention as assessed by TAM3 (Technology Acceptance Model 3) questionnaire. | Number of participants with high level of behavioral intention (TAM3 score range 1-7), with higher scores indicating greater acceptability of intervention. | Measured at discharge or 7 days post baseline |
| Feasibility: Perceived usability of a technological system or application as assessed by SUS (System Usability Scale) | Number of participants with high level of high level of behavioral intention (SUS score range 1-5), high score indicating greater perceived usability of a technological system or application | Measured at discharge or 7 days post baseline |
| Feasibility: User experience of intervention as assessed by UEQ (User Experience Questionnaire) | Number of participants with high level of comprehensive impression of user experience (UEQ score range 1-7), with higher scores indicating greater impression of user experience. | Measured at discharge or 7 days post baseline |
| Feasibility: Intrinsic motivation as assessed by IMI subscale (Intrinsic Motivation Inventory). | Number of participants with high level of behavioral intention (IMI score range 1-7), with higher scores indicating greater intrinsic motivation. | Measured at discharge or 7 days post baseline |
| Feasibility: Sickness elicited by modern virtual reality systems as assessed by SSQ (Simulator Sickness Questionnaire). | Number of subjects with high level of sickness (SSQ score range 0-3), with higher scores indicating greater simulator sickness. | Measured at discharge or 7 days post baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Language | Changes in phonemic/semantic language ability as assessed by Verbal Fluency | Measured at baseline and at the end of the rehabilitation sessions (6 weeks) |
| Working memory and attention |
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Inclusion Criteria for patients:
Exclusion criteria for patients:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fondazione Don Gnocchi | Milan | Italy |
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| ID | Term |
|---|---|
| D009422 | Nervous System Diseases |
| D009103 | Multiple Sclerosis |
| D010300 | Parkinson Disease |
| D020521 | Stroke |
| D000070642 | Brain Injuries, Traumatic |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D003711 | Demyelinating Diseases |
| D001327 | Autoimmune Diseases |
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| ID | Term |
|---|---|
| D000091942 | Cognitive Training |
| ID | Term |
|---|---|
| D000066530 | Neurological Rehabilitation |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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Changes in executive functioning as assessed by Trial Making Test
| Measured at before and at the end of the rehabilitation sessions (6 weeks) |
| Visual-spatial ability | Changes in visual-spatial ability as assessed by Rey Figure | Measured at before and at the end of the rehabilitation sessions (6 weeks) |
| Social metrics | Proximity, frequency of interactions, synchrony and coordination. All these parameters will be measured by sensors | Measure recorded during all rehabilitative sessions (6 weeks) |
| Emotional state | Changes in positive and negative affective states as assessed by Positive and Negative Affect Schedule | Measured at baseline and at the end of the rehabilitation sessions (6 weeks) |
| Social cognition | Changes in theory of mind ability as assessed by Yoni task-48 | Measured at baseline and at the end the rehabilitation sessions (6 weeks) |
| Gross manual dexterity level | Changes in gross manual dexterity level as assessed by Box and Block | Measured at baseline and at the end the rehabilitation sessions (6 weeks) |
| Global cognitive functioning | Changes in general cognitive funtioning as assessed by MoCA | Measured at baseline and at the end the rehabilitation sessions (6 weeks) |
| Episodic memory | Changes in episodic memory as assessed by FCRST | Measured at baseline and at the end the rehabilitation sessions (6 weeks) |
| D007154 | Immune System Diseases |
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D002561 | Cerebrovascular Disorders |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D001930 | Brain Injuries |
| D006259 | Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |