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| ID | Type | Description | Link |
|---|---|---|---|
| 2021/10/889 | Other Identifier | University of Salamanca |
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This randomized controlled clinical trial evaluates the impact of non-surgical periodontal therapy on systemic inflammatory markers in patients with chronic prostatitis or recurrent urinary tract infections. Emerging evidence suggests a possible association between periodontal inflammation and genitourinary conditions.
A total of 60 male participants diagnosed with periodontitis and either chronic prostatitis or recurrent urinary tract infections were randomly assigned to one of three groups: non-surgical periodontal therapy, oral hygiene instruction only, or no periodontal treatment. The primary outcomes were changes in serum prostate-specific antigen (PSA) levels and the frequency of positive urine cultures over a 120-day follow-up period.
The study aims to investigate whether periodontal treatment may reduce systemic inflammatory burden and improve genitourinary clinical parameters.
This parallel-group randomized clinical trial was conducted at a university healthcare center. Eligible participants were adult male patients diagnosed with periodontitis and chronic prostatitis (NIH category III) or recurrent urinary tract infections.
Participants were randomly allocated to receive full-mouth scaling and root planing combined with oral hygiene instruction, oral hygiene instruction alone, or no periodontal intervention during the study period.
Clinical periodontal parameters, serum PSA levels, and microbiological urine cultures were assessed at baseline and at 120 days. Statistical analyses were performed to evaluate intergroup differences and longitudinal changes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Non-Surgical Periodontal Therapy | Experimental | Participants received full-mouth scaling and root planing combined with oral hygiene instruction. |
|
| Oral Hygiene Instruction | Active Comparator | Participants received standardized oral hygiene instructions without mechanical periodontal treatment. |
|
| Control | No Intervention | Participants did not receive periodontal treatment during the 120-day follow-up period. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non-surgical periodontal therapy | Procedure | Full-mouth scaling and root planing performed under local anesthesia using ultrasonic and hand instruments, completed within two sessions over a one-week period. Participants also received standardized oral hygiene instructions including tooth brushing technique and interdental cleaning guidance. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in serum prostate-specific antigen (PSA) levels | Difference in serum prostate-specific antigen (PSA) levels measured in ng/mL between baseline and 120 days after intervention. | Baseline to 120 days |
| Measure | Description | Time Frame |
|---|---|---|
| Change in frequency of positive urine cultures | Difference in the number of microbiologically confirmed urinary tract infections between baseline and 120 days. | Baseline to 120 days |
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Inclusion Criteria:
Exclusion Criteria:
Severe systemic diseases affecting inflammatory status
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Salamanca | Salamanca | Spain |
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Participants were randomly assigned in a parallel design to one of three groups: non-surgical periodontal therapy, oral hygiene instruction, or no periodontal treatment, with a 120-day follow-up period.
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Due to the nature of the intervention, blinding of participants and care providers was not feasible.
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| Oral hygiene instruction | Behavioral | Standardized oral hygiene instructions including tooth brushing technique, use of interdental cleaning devices, and reinforcement of plaque control measures, without mechanical periodontal instrumentation. |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D014552 | Urinary Tract Infections |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D007239 | Infections |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
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