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This study aims to analyze the effects of physical activity in patients with chronic kidney disease undergoing dialysis or conservative treatment. Patients will be randomized into two groups: combined exercise (high-intensity aerobic resistance + strength training) and control group
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| combined exercise | Experimental | participants will undergo a combined endurance and resistance exercise training |
|
| control group | Active Comparator | participants performs outcome measures sessions only, including blood sample collection. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Other | All participants will be involved in the exercise training three times per week for 24 weeks: endurance exercise training, resistant exercise training |
|
| Measure | Description | Time Frame |
|---|---|---|
| Gait speed (6MWT) | • Assess the effect of exercise on physical performance and quality of life on pa-tients with chronic kidney disease from stage 1 to end stage renal disease on maintenance haemodialysis or on conservative treatment | through study completion, an average of 1 year |
| Physical performance (SPPB) | through study completion, an average of 1 year | |
| Cardiopulmonary capacity (CPET) | through study completion, an average of 1 year | |
| Lower limbs strength (1-RM) | through study completion, an average of 1 year | |
| Maximum isometric strength of the upper limb (hand grip) | through study completion, an average of 1 year | |
| Daily physical activity amount (IPAQ) | through study completion, an average of 1 year | |
| Quality of life (SF36) | through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Nutritional status (24HR, FFQ) | through study completion, an average of 1 year | |
| Body composition (DEXA, BIVA) | through study completion, an average of 1 year | |
| Measure | Description | Time Frame |
|---|---|---|
| effect of physical activity on mitochondrial activity | Investigate the effect of physical activity on mitochondrial activity by analyzing the expression of mitochondrial biomarkers, MOTS-c (mg) | through study completion, an average of 1 year |
| Effect of physical activity on mitochondrial activity |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ospedale P. Pederzoli Casa di Cura Privata S.p.A. | Recruiting | Peschiera del Garda | Verona | 37019 | Italy |
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| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| control | Other | outcome measures |
|
| Psychological and psychosocial conditions (BDI, MMSE) |
| through study completion, an average of 1 year |
| Hemodynamic and vascular functions (SV, CO, HR, FBF, FMD, sPLM) | through study completion, an average of 1 year |
| Muscular oxygen extraction (NIRS) | through study completion, an average of 1 year |
| Neuromuscular functions (MCV, RFD) | through study completion, an average of 1 year |
Investigate the effect of physical activity on mitochondrial activity by analyzing the expression of mitochondrial biomarkers, humanin (mg) |
| through study completion, an average of 1 year |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |