Effect of Exercise on Renal Function in Predialysis

The Effect of Exercise on Renal Function and Cardiovascular Disease in Pre-dialysis (Chronic Kidney Disease Stage 3-4) Patients With Chronic Kidney Disease; a Randomised Controlled Trial Pilot Study.

The proposed research aims to examine whether regular aerobic exercise can preserve renal function, improve aerobic capacity, physical and psychosocial function, strength, cardiovascular function, general well-being and quality of life. Ultimately, the research aims to prove that exercise is a more cost-effective and a more efficient use or healthcare resources used in the treatment of patients with CKD. Exercise is a relatively cheap treatment option which is readily available and accessible for this patient population. establish if, compared with usual care, an exercise programme for pre-dialysis CKD patients;

1. Preserves renal function.
2. Improves aerobic capacity, physical and psychosocial function, strength, cardiovascular function, general well-being and quality of life.

Inclusion Criteria:

• - Stages 3-4 chronic kidney disease (CKD) patients (glomerular filtration rate (GFR) 20-60 mL/min)
• Male or female
• Aged >18 years
• Written informed consent

Exclusion Criteria:

• Pregnancy

  • Requiring support for ambulation less than 20m
  • Vasculitis,
  • Proliferative diabetic retinopathy,
  • Severe osteodystrophy,
  • Uncontrolled diabetes,
  • Psychiatric illness, including anxiety, mood and untreated eating disorders
  • Infection or course of antibiotics within the last month