Piloting an Insomnia Treatment in Patients With Ulcerative Colitis

Piloting an Insomnia Treatment in Patients With Ulcerative Colitis

The goal of this clinical trial is to learn if telehealth-based Cognitive Behavioral Therapy for Insomnia (CBT-I) adapted for Ulcerative Colitis (UC) works to treat insomnia in adults with UC. The main questions it aims to answer are:

• Is telehealth-based CBT-I adapted for UC feasible and acceptable to participants?
• Does CBT-I for UC impact insomnia severity and sleep continuity?

Participants will:

• Answer questionnaires online before and after treatment
• Complete an online daily sleep diary before, during, and after treatment
• Participate in 5 telehealth treatment visits over 7-8 weeks
• Participate in 5-10-minute phone calls between treatment visits

Inclusion Criteria:

• Active UC based on PRUCSI
• Insomnia Severity Index score > 8 and SOL or WASO > 30 minutes
• Stability of sleep & UC meds for > 3 months
• Access to internet or cell phone service sufficient for telehealth

Exclusion Criteria:

• PHQ-9 depression score > 15
• GAD-7 anxiety score > 15
• Unstable major psychiatric condition (e.g., bipolar disorder, psychotic disorder)
• Current alcohol or substance abuse
• Current opioid use for pain control
• Current systemic corticosteroid use
• Current pregnancy or nursing
• Ileostomy or colostomy
• Diagnosis of seizure disorder
• Diagnosis of sleep apnea
• Diagnosis of restless leg syndrome or positive Cambridge-Hopkins RSLq screen
• Night shift, rotating shift work, or frequent travel outside of time zone
• Residence in a state where we cannot conduct telehealth visits