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The primary purpose of the research is to evaluate in healthy adults the time course effects of energy drink formulas containing 120 mg caffeine with varying levels of taurine and b vitamins on subjective alertness in the presence of cognitive load assessed hourly up to 5 hours post dose
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo beverage | Placebo Comparator | Base carbonated beverage with no caffeine, taurine, or vitamins |
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| Caffeine 120 mg beverage 1 | Experimental | Carbonated beverage with varying levels of taurine and B vitamins |
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| Caffeine 120 mg beverage 2 | Experimental | Carbonated beverage with varying levels of taurine and B vitamins |
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| Caffeine 120 mg beverage 3 | Experimental | Carbonated beverage with varying levels of taurine and B vitamins |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| All beverages are flavor and color matched | Other | Caffeine with varying amounts of taurine and B vitamins |
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| Measure | Description | Time Frame |
|---|---|---|
| Caffeine Research Visual Analog Scale (VAS) subjective alertness factor adapted from Rogers et al. | Subjective 'alert' and 'tired' ratings combined to create a composite alertness factor. Alert ratings assessed by placing an 'x' on a line representing 0-100 to match their current state; tired ratings assessed by placing an 'x' on a line representing 0-100 to match their current state. Higher alert ratings represent a better outcome, higher tired ratings represent a worse outcome and are reversed to create the composite score, which is the average of the two scales and is scored 0-100 with higher scores representing a better outcome. | Change from baseline Time 0 to 240 minutes post-dose |
| Measure | Description | Time Frame |
|---|---|---|
| Caffeine Research VAS measures (Visual Analog Scale) subjective tension factor adapted from Rogers et al. | Subjective 'relaxed' and 'tense' ratings combined to create a composite tension factor. Relaxed ratings assessed by placing an 'x' on a line representing 0-100 to match their current state; tense ratings assessed by placing an 'x' on a line representing 0-100 to match their current state. Higher tense ratings represent a worse outcome, higher relaxed ratings represent a better outcome and are reversed to create the composite score, which is the average of the two scales and is scored 0-100 with higher scores representing a worse outcome. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Crystal Haskell-Ramsay, PhD | Northumbria U Newcastle, UK | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Northumbria U | Newcastle | Tyne | NE1 7RU | United Kingdom |
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| Flavored carbonated beverage, color-matched | Other | Base with 0 mg caffeine, taurine, vitamins |
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| Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose |
| Simple reaction time | Cognitive function - attention measured as reaction time (in milliseconds), with a lower score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS) | Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes ) |
| Digit vigilance accuracy | Cognitive function - attention measured as a percentage, with a higher score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS) | Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes ) |
| Digit vigilance reaction time | Cognitive function - attention measured as reaction time (in milliseconds), with a lower score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS) | Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes ) |
| Digit vigilance false alarms | Cognitive function - attention measured as number of errors, with a lower score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS) | Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes ) |
| Choice reaction accuracy (%) | Cognitive function - attention measured as a percentage, with a higher score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS) | Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes ) |
| Choice reaction accuracy (milliseconds) | Cognitive function - attention measured as reaction time (in milliseconds), with a lower score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS) | Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes ) |
| Rapid visual information processing accuracy | Cognitive function - attention measured as a percentage, with a higher score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS) | Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes ) |
| Rapid visual information processing reaction time | Cognitive function - attention measured as reaction time (in milliseconds), with a lower score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS) | Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes ) |
| Rapid visual information processing false alarms | Cognitive function - attention measured as number of errors, with a lower score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS) | Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes ) |