There are extensive gaps in the local data considering pregabalin versus gabapentin as pre-emptive analgesics in patients undergoing orthopedic surgeries under spinal anesthesia. Therefore, the current study was planned with the objective of comparing pregabalin versus gabapentin as pre-emptive analgesics in patients undergoing orthopedic surgeries under spinal anesthesia.

Since postoperative pain in orthopedic surgery, whether neuropathic or nociceptive, presents a significant challenge for both surgeons and patients, knowing the more effective gabapentinoid as a pre-emptive analgesic would help clinicians to offer prolonged timing of first rescue analgesia and less opioid consumption.

Inclusion Criteria:

• Either gender
• Aged 20-60 years
• Undergoing lower limb orthopedic surgeries under spinal anesthesia

Exclusion Criteria:

• Patients with a previous history of spine interventions, including surgery or injections (transforaminal, epidural, or facetal) for pain relief
• Patients under any sort of pain modulation therapy, like transcutaneous electrical nerve stimulation
• Patients had a long-term history of any analgesia use
• Those with psychiatric disorders, alcohol/drug dependence, hepatic, renal, cardiac, or pulmonary abnormalities,
• With a history of allergies to gabapentinoids

Data can be shared on a reasonable request.