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This is a single-center prospective cohort study to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.
The primary objective of this study is to determine whether a two-week course of daily ACV supplementation significantly changes an individual's urine chemistry. The investigators will study this in healthy individuals and individuals with kidney stones.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| kidney stone patients and healthy participants | Experimental | Each participant will be asked to complete a basic metabolic panel prior to initiating the study to ensure that no baseline metabolic derangements exist. On day 1, participants will complete a 24-hour urine collection and 48-hour food diary at home. Participants will then consume an ACV gummy containing 60 meq daily for 14 consecutive days. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Apple Cider Vinegar | Dietary Supplement | Goli Apple Cider Vinegar gummies |
|
| Measure | Description | Time Frame |
|---|---|---|
| Measure changes in citrate in urine. | to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry. | From Enrollment to 2 weeks |
| Measure changes in Urine PH | to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry. | From enrollment to 2 weeks |
| Measure changes in calcium in urine. | to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry. | from enrollment to 2 weeks |
| Measure changes in calcium oxalate in urine | to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry. | From Enrollment to 2 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Luke Reynolds | Contact | 7137926105 | lukereynolds@bsd.uchicago.edu |
| Name | Affiliation | Role |
|---|---|---|
| Luke Reynolds | The University of Chicago Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Chicago | Chicago | Illinois | 60637 | United States |
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| ID | Term |
|---|---|
| D007669 | Kidney Calculi |
| ID | Term |
|---|---|
| D053040 | Nephrolithiasis |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052878 | Urolithiasis |
| D014545 | Urinary Calculi |
| D052801 | Male Urogenital Diseases |
| D002137 | Calculi |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |