There are considerable gaps in the comparative effectiveness and tolerability of myo-inositol and metformin for treating obesity in patients with polycystic ovarian syndrome (PCOS). The current study aimed to give insights comparing myo-inositol versus metformin for treating obesity in patients with PCOS.

A review of the literature reveals inconsistent outcomes of myo-inositol vs metformin in the treatment of obesity and metabolic disorders in patients with PCOS, with comparable results and myo-inositol frequently demonstrating superior tolerability and reduced gastrointestinal side effects relative to metformin. When treating obesity in women with PCOS, practicing gynecologists would be able to select more appropriate medications by gathering data from local contexts. It will lessen psychological consequences associated with obesity, such as discrimination, stigma, low self-esteem, and poor quality of life.

Inclusion Criteria:

• Females aged 18-45 years
• Diagnosed case of PCOS for more than 6 months of duration

Exclusion Criteria:

• Women with hyperprolactinemia or hypothyroidism (on history & medical record review)
• Adrenal hyperplasia or Cushing's syndrome (on history & medical record review)

Data can be shared on a reasonable request.