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The study aimed to assess how a 6-month insulin sensitizer therapy impacts insulin resistance, glucose tolerance, and hormonal levels in women with PCOS. Researchers evaluated 156 PCOS patients, measuring their BMI, HOMA-IR (for insulin resistance), TyG index, TyG index-BMI, and total testosterone. Participants were divided into two groups, receiving either metformin or a myoinositol/d-chiro-inositol combination for six months, after which all parameters were re-evaluated to determine the percentage of change.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Myoinositol Group | Active Comparator | Patients presenting manifestations suggestive of having PCOS were evaluated for enrollment in the study, and took the tablets containing myoinositol/d-chiro-inositol combination (MYO/DCI) in 40:1 ratio |
|
| Metformin Group | Active Comparator | Patients presenting manifestations suggestive of having PCOS were evaluated for enrollment in the study, and took metformin (MET) hydrochloride 500 mg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Metformin Hydrochloride 500 MG | Drug | metformin (MET) hydrochloride 500 mg three times daily as the standard insulin sensitizer. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Success Rate of Treatment Regimens in Restoring Menstrual Regularity and/or Achieving Pregnancy | The proportion of patients who regained a regular menstrual pattern and/or achieved pregnancy during the study, reflecting the effectiveness of the administered treatment regimens. | 6~7 Months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Benha university | Banhā | El Qalyoubia | 13511 | Egypt |
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| ID | Term |
|---|---|
| D008687 | Metformin |
| D007294 | Inositol |
| ID | Term |
|---|---|
| D001645 | Biguanides |
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
| D013402 |
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| Myoinositol | Drug | myoinositol/d-chiro-inositol combination (MYO/DCI) in 40:1 ratiotwice daily |
|
|
| Sugar Alcohols |
| D000438 | Alcohols |
| D002241 | Carbohydrates |