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This study will elucidate the role of 3D transvaginal ultrasound in assessing (1) cervical vascularity and blood flow in patients with cervical cancer and cervical intraepithelial neoplasm, and (2) tumor vascularity and blood flow in patients with ovarian cancer.
Patients and methods:
Women with cervical cancer, cervical intraepithelial neoplasm, ovarian cancer, or the control will be invited to particilate in this study.Then, 3D power Doppler Ultrasound will be performed to capture (1) the cervical volume, vascularity and blood perfusion, and (2) ovarian tumor vascularity and blood perfusion. The sonographic data will be correlated to clinical and pathological data.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cervical cancer | cervical cancer patients |
| |
| cervical intraepithelial neoplasm | cervical intraepithelial neoplasm patients |
| |
| control | Gynecological patients without cervical disease |
| |
| ovarian cancer | ovarian cancer patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Doppler ultrasound | Diagnostic Test | 3D doppler ultrasound to measure VI, FI, VFI. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Vascularization-flow index |
| 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Vascularization index | 1. Compare the vascularization index values between cervical cancer, cervical intraepithelial neoplasia and the control group. 2. To assess whether vascularization index is a predictor of progression-free survival in women with ovarian cancer | 3 years |
| Flow index |
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Inclusion Criteria:
Regarding the topic "Hemoperfusion characteristics of cervical cancer and precancerous lesions, and the correlation between hemoperfusion and prognosis":
Regarding the topic "Correlation between hemoperfusion and prognosis of ovarian cancer":
Exclusion Criteria:
Regarding the topic "Hemoperfusion characteristics of cervical cancer and precancerous lesions of the cervix, and the correlation between hemoperfusion and prognosis":
1. Patients who cannot cooperate with vaginal 3D ultrasound scans.
Regarding the topic "Correlation between hemoperfusion and prognosis of ovarian cancer":
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Women with cervical cancer, cervical intraepithelial neoplasm, ovarian cancer, and the disease-free control
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, | New Taipei City | Banqiao | 22050 | Taiwan |
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| ID | Term |
|---|---|
| D002583 | Uterine Cervical Neoplasms |
| D002578 | Uterine Cervical Dysplasia |
| D010051 | Ovarian Neoplasms |
| ID | Term |
|---|---|
| D014594 | Uterine Neoplasms |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
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| ID | Term |
|---|---|
| D018608 | Ultrasonography, Doppler |
| ID | Term |
|---|---|
| D014463 | Ultrasonography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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1. Compare the flow index values between cervical cancer, cervical intraepithelial neoplasia and the control group. 2. To assess whether flow index is a predictor of progression-free survival in women with ovarian cancer |
| 3 years |
| Far Eastern Memorial Hospital | New Taipei City | 220 | Taiwan |
|
| D009369 |
| Neoplasms |
| D002577 | Uterine Cervical Diseases |
| D014591 | Uterine Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D011230 | Precancerous Conditions |
| D004701 | Endocrine Gland Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D004700 | Endocrine System Diseases |
| D006058 | Gonadal Disorders |