Phase I Pilot Study to Evaluate the Prognostic Value of Perfusion CT for Primary Cervical Cancer

Phase I Pilot Study to Evaluate the Prognostic Value of Perfusion CT for Primary Cervical Cancer

The investigators hope to learn whether perfusion CT is a useful way to assess primary cervical tumor microenvironment and whether there is a relationship between pretreatment perfusion CT measurements and primary cervical tumor size, lymph node involvement (as assessed by standard of care pretreatment fludeoxyglucose Positron emission tomography/CT (FDG-PET/CT)), and treatment response (as assessed by standard of care 3-month post-therapy FDG-PET/CT).

Inclusion criteria:

• >18 years old
• with biopsy-proven squamous, adenocarcinoma or adenosquamous cervical cancer
• no history of prior pelvic radiation and should be able to receive chemoradiation
• non-pregnant women who have not previously undergone a hysterectomy, as that would have removed the cervix.
• able to give informed consent

Exclusion criteria:

• Subjects whose tumors are not FDG avid on the pre-therapy PET.
• Allergy or inability to receive iodinated CT contrast