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The Goal of this Clinical trial is to compare the efficacy of oral azithromycin alone with combination therapy of oral azithromycin and probiotics to see is there any significant difference in outcome of two treatment modalities in mild to moderate acne vulgaris
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oral Azithromycin group | Active Comparator | The participants in this arm of study will receive only Oral Azithromycin to treat their Acne |
|
| Oral Azithromycin and Oral probiotic combination | Active Comparator | The participants in this arm of study will receive both Oral Azithromycin and Oral Probiotics to treat their Acne |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Azithromycin 250 MG Oral Capsule | Drug | The participants in this arm of study will receive only Oral Azithromycin 250mg on alternate day for 12 weeks to treat their Acne |
|
| Measure | Description | Time Frame |
|---|---|---|
| Reduction of Acne Lesion Count as per Acne Global assessment scale | The patients will be assessed before and after the treatment and their lesions will be counted .The Primary outcome that will be measured is the reduction of the lesion counts according to the Acne global Assessment scale The participants included will be with mild to moderate acne on basis of global acne assessment scale score of 2 or 3. The minimum Lesion count considered will be 20 and the Maximum will be 50. Lower is better Higher is worse. | 12 Weeks |
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Inclusion Criteria: Participants with mild to moderate acne on basis of global acne assessment scale score of 2 or 3 and with 20 to 50 total lesion count will be included.
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Exclusion Criteria:
History of active localized or generalized infection History of autoimmune disease History of other facial skin diseases/ excessive facial hair or scars History of using isotretinoin or oral contraceptive pills in past 6 months History of already using antibiotics for acne treatment History of facial cosmetic procedures within last 3 months History of allergy to drugs used in study History of using drugs that may interact with azithromycin Currently pregnant or lactating women
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| Name | Affiliation | Role |
|---|---|---|
| Ayesha Naeem | Hayatabad Medical Complex Peshawar, KPK Pakistan | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hayatabad Medical Complex | Peshawar | Pakistan |
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| Azithromycin 250 MG Oral Capsule Along with Oral Probiotics | Drug | The participants in this arm of study will receive only Oral Azithromycin 250mg on alternate day along with oral probiotics daily for 12 weeks to treat their Acne |
|
| ID | Term |
|---|---|
| D017963 | Azithromycin |
| D019936 | Probiotics |
| ID | Term |
|---|---|
| D004917 | Erythromycin |
| D018942 | Macrolides |
| D061065 | Polyketides |
| D007783 | Lactones |
| D009930 | Organic Chemicals |
| D019587 | Dietary Supplements |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
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