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The aim of this study is to compare between conventional Total Knee Arthroplasty (TKA) and Total Knee Arthroplasty (TKA) combined with intra-operative Genicular Nerve Radio-Frequency Ablation (GNRFA), concerning post-operative functional outcome and pain scores in patients with advanced knee osteoarthritis
The aim of this study is to compare between conventional Total Knee Arthroplasty (TKA) and Total Knee Arthroplasty (TKA) combined with intra-operative Genicular Nerve Radio-Frequency Ablation (GNRFA), concerning post-operative functional outcome and pain scores in patients with advanced knee osteoarthritis
Including 70 knees randomized using a computer-generated sequence into two groups, the first group underwent TKA combined with GNRFA, and the other group underwent TKA only. All the TKA surgeries were performed by a single surgeon including patients aged from fifty to eighty years with advanced primary knee osteoarthritis from both sexes
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Active Comparator | underwent Total knee arthroplasty only |
|
| Genicular nerve radio-frequency ablation | Experimental | underwent Total knee arthroplasty with genicular nerve radio-frequency ablation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Total knee arthroplasty | Procedure | Conventional Total knee arthroplasty operation performed |
|
| Measure | Description | Time Frame |
|---|---|---|
| Post operative pain | pain assessment using Visual analogue scale, minimum value is 0 meaning no pain and maximum value is 10 meaning the worst pain, higher score means worse outcome | 6 months post operative |
| Post operative knee functional outcome | measuring the knee functional outcome post operative using oxford knee score, minimum score is 0 meaning the worse outcome and maximum is 48 meaning the best outcome. higher score means better outcome | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Assem Mohamed Mahmoud Ahmed, MD | Ain Shams University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams University | Cairo | Abbassia | 00202 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42035153 | Derived | Ahmed AMM, Kotb AS, Khairy A, El Ganzoury I, Abdelazim H, Mohasseb AM. Is genicular nerve radio frequency ablation the key to improving patients' satisfaction after total knee arthroplasty? a randomised controlled trial. J Orthop Surg Res. 2026 Apr 25;21(1):289. doi: 10.1186/s13018-026-06855-8. |
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No need to contact them
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Jan 12, 2022 | Jan 30, 2026 | Prot_001.pdf |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D019645 | Arthroplasty, Replacement, Knee |
| ID | Term |
|---|---|
| D019643 | Arthroplasty, Replacement |
| D001178 | Arthroplasty |
| D019637 | Orthopedic Procedures |
| D013514 | Surgical Procedures, Operative |
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| Genicular nerve radiofrequency ablation | Procedure | Genicular nerve radiofrequency ablation done with no modifications except being performed with total knee arthroplasty in the same setting |
|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D019651 | Plastic Surgery Procedures |
| D019919 | Prosthesis Implantation |