Effect of Rutin on Inflammation Pathways in Ulcerative Colitis Patients

Rutin Therapy Reduces Ulcerative Colitis Disease Activity By Inhibiting The NOD-Like Receptor Protein 3 (NLRP3) Inflammasome: A Molecular Assessment in an Interventional Study.

This study evaluates the therapeutic role of Rutin (a plant-derived flavonoid) in reducing the severity of Ulcerative Colitis (UC). The study investigates whether Rutin can decrease intestinal inflammation and improve clinical symptoms by inhibiting the NLRP3 inflammasome signaling pathway, which is activated by oxidative stress in the colon.

Inclusion Criteria:

• Diagnosis of UC confirmed by endoscopy/histology.
• Age 18 to 65 years.

Exclusion Criteria:

• Pregnancy or breastfeeding.
• Known hypersensitivity to Rutin.
• Presence of other serious systemic diseases (e.g., malignancy, severe hepatic or renal failure).