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This study evaluates the therapeutic role of Rutin (a plant-derived flavonoid) in reducing the severity of Ulcerative Colitis (UC). The study investigates whether Rutin can decrease intestinal inflammation and improve clinical symptoms by inhibiting the NLRP3 inflammasome signaling pathway, which is activated by oxidative stress in the colon.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active Ulcerative Colitis (UC-A) | Active Comparator |
| |
| Remission Ulcerative Colitis (UC-B) | Active Comparator |
| |
| Healthy Control (Group C) | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rutin 500 MG Oral Tablet | Drug | Oral capsules twice daily for 30 days |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Success Rate of Clinical Improvement | The percentage of participants who achieve clinical improvement at the end of the treatment period. Clinical improvement is defined as reaching a score of 5 or less on the Simple Clinical Colitis Activity Index (SCCAI). | Day 30 (End of treatment) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Fecal Calprotectin Levels | The concentration of Fecal Calprotectin measured in stool samples to quantify the reduction in intestinal inflammation. | Baseline and Day 30 |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Benha Faculty of Medicine | Banhā | Al Qalyoubia | 13511 | Egypt |
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| ID | Term |
|---|---|
| D003093 | Colitis, Ulcerative |
| ID | Term |
|---|---|
| D003092 | Colitis |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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| ID | Term |
|---|---|
| D012431 | Rutin |
| D013607 | Tablets |
| ID | Term |
|---|---|
| D044948 | Flavonols |
| D005419 | Flavonoids |
| D002867 | Chromones |
| D001578 | Benzopyrans |
| D011714 |
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| Fecal Calprotectin |
| Diagnostic Test |
Sample collection only for baseline comparison. |
|
| Placebo | Drug | Placebo tablets for 30 days |
|
| D015212 |
| Inflammatory Bowel Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| Pyrans |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D004304 | Dosage Forms |
| D004364 | Pharmaceutical Preparations |