Serum CPK and Creatinine Changes During Plyometric Traini... | NCT07356193

Studies
Serum CPK and Creatinine Changes During Plyometric Training in Collegiate Athletes

NCT07356193

Sponsor

Batterjee Medical College

Status

Completed

Last Update Posted

Jan 22, 2026Actual

Enrollment

62Actual

Phase

Not Applicable

Conditions

Muscle Damage
Plyometric Exercises
Creatine Kinase
Exercise Physiology

Interventions

Lower Body Plyometric Training
control group

Countries

Saudi Arabia

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Jan 2026

Overall Recruitment Status or Expanded Access Status

Completed

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Feb 13, 2022Actual

Primary Completion Date

Aug 10, 2022Actual

Completion Date

Dec 28, 2022Actual

First Submitted Date

Jan 11, 2026

First Submission Date that Met QC Criteria

Jan 11, 2026

First Posted Date

Jan 21, 2026Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Jan 21, 2026

Last Update Posted Date

Jan 22, 2026Actual

Sponsor/Collaborators Module

Responsible Party, by Official Title

Mohamed A. Abdel Ghafar, Professor, Batterjee Medical CollegePrincipal Investigator

Lead Sponsor

Batterjee Medical CollegeOTHER

Collaborators

Not provided

Oversight Module

Has Data Monitoring Committee (DMC)

Is FDA Regulated Drug

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

Not provided

FDAAA801 Violation

Not provided

Description Module

Brief Summary

This retrospective study evaluated the effects of an eight-week lower body plyometric training program on serum creatine phosphokinase (CPK) and creatinine levels in male collegiate volleyball players. Sixty two players were divided into experimental and control groups. CPK and creatinine were measured at baseline and multiple time points during training. The study assessed whether plyometric training produced harmful biochemical changes or signs of rhabdomyolysis.

Detailed Description

This study evaluated the physiological effects and safety of an eight-week lower body plyometric training program in male collegiate volleyball players, focusing on changes in serum creatine phosphokinase (CPK) and creatinine levels. Sixty two healthy athletes were randomly assigned to either a plyometric training group or a control group. The experimental group performed progressive lower body plyometric exercises twice weekly for eight weeks, while the control group continued regular volleyball training.

Serum CPK and creatinine were assessed at baseline and multiple time points throughout the intervention. CPK levels in the training group increased significantly early in the program, peaking on Day 4 and remaining elevated until Week 2, before returning to baseline by Week 8. Importantly, all values remained within normal clinical ranges, and no signs of rhabdomyolysis or overtraining were observed. Serum creatinine levels showed no significant changes, indicating preserved renal function. No biomarker changes were detected in the control group.

These findings indicate that an eight-week, progressively designed plyometric training program is safe and well tolerated in male collegiate volleyball players.

Design Module

Study Type

Interventional

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Not provided

Target Follow-Up Duration

Not provided

Phases

Not Applicable

Interventional Study Design

Allocation

Biospecimen

No data available

No data is available for this block.

Enrollment

62Actual

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Lower Body Plyometric Training	Experimental		Behavioral: Lower Body Plyometric Training Other: control group
Control Group	Active Comparator		Other: control group

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Lower Body Plyometric Training	Behavioral	Training twice weekly for eight weeks, including low-, moderate-, and high-intensity plyometric exercises (squat jumps, box jumps, tuck jumps, split squat jumps, lateral hurdle jumps, zigzag jumps, single-leg tuck jumps, and depth jumps).

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Serum Creatine Phosphokinase (CPK) Levels	Change in serum CPK measured using the CK-NAC optimized IFCC method.	Baseline; Day 2; Day 4; Week 1; Week 2; Week 4; Week 6; Week 8

Secondary Outcomes

Measure	Description	Time Frame
Serum Creatinine Levels	Measured using modified Jaffe's method.	Baseline; Day 2; Day 4; Week 1; Week 2; Week 4; Week 6; Week 8

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

male collegiate volleyball players
Age: 18-20 years
No prior plyometric training

Exclusion Criteria:

History of kidney disease
Current musculoskeletal injury
neuromuscular impairments

Accepts Healthy Volunteers

Yes

Sex

Male

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

20 Years

Standard Ages

Adult

Study Population

Not provided

Sampling Method

Not provided

Contacts/Locations Module

Central Contacts

Not provided

Overall Officials

Not provided

Locations

Facility	Status	City	State	ZIP	Country	Contacts
Batterjee Medical College		Jeddah			Saudi Arabia

IPD Sharing Statement Module

Plan to Share IPD

Description

IPD will not be shared because participant consent did not include permission for data sharing and the dataset contains sensitive physiological information.

Types

Not provided

Time Frame

Not provided

Access Criteria

Not provided

URL

Not provided

Intervention Browse Module

MeSH Terms

ID	Term
D035061	Control Groups

Ancestor Terms

ID	Term
D015340	Epidemiologic Research Design
D004812	Epidemiologic Methods
D008919	Investigative Techniques
D012107	Research Design

Browse Leaves

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Browse Branches

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