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The objective of this observational study is to compare the relative concentrations of various thrombo-inflammatory markers at different follow-up time points in:
The main question this study aims to answer is: How do thrombo-inflammatory marker concentrations evolve over time and differ between patients? Researchers will compare patients with or without delayed cerebral ischemia after subarachnoid hemorrhage, as well as patients with or without rapid progression of necrotic volume following an ischemic stroke due to large- or medium-vessel occlusion in the anterior circulation, to determine whether there are differences in thrombo-inflammatory marker concentrations and in their evolution over time.
Participants will undergo blood sampling at five different time points. In addition, participants will complete a Montreal Cognitive Assessment (MoCA) questionnaire during the 3-month follow-up visit.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AIC | Patient with rapid progression of necrotic volume after an ischemic stroke due to large- or medium-vessel occlusion in the anterior circulation | ||
| HSA | Patient with delayed cerebral ischemia after subarachnoid hemorrhage | ||
| healthy volunteer | healthy volunteer |
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| Measure | Description | Time Frame |
|---|---|---|
| Investigation of changes in thrombo-inflammatory marker concentrations between patients and over time. | Investigation of changes in thrombo-inflammatory marker concentrations between patients and over time. | From enrollment to Month 3 visit |
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Inclusion Criteria:
Exclusion Criteria:
Patients with acute ischemic stroke and NIHSS > 5 without LVO or MeVO of the anterior circulation on imaging will be secondarily excluded. Perfusion imaging will not be performed as part of the research protocol. Excluded patients will be replaced.
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Among patients treated at Liège University Hospital.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| François Delvoye, MD, PhD | Contact | 04/3236630 | fdelvoye@chuliege.be | |
| Simon Detriche, PhD | Contact | 043236684 | sdetriche@chuliege.be |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30904732 | Background | Ray B, Ross SR, Danala G, Aghaei F, Nouh CD, Ford L, Hollabaugh KM, Karfonta BN, Santucci JA, Cornwell BO, Bohnstedt BN, Zheng B, Dale GL, Prodan CI. Systemic response of coated-platelet and peripheral blood inflammatory cell indices after aneurysmal subarachnoid hemorrhage and long-term clinical outcome. J Crit Care. 2019 Aug;52:1-9. doi: 10.1016/j.jcrc.2019.03.003. Epub 2019 Mar 14. | |
| 23589781 |
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Accessible upon request after publication
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| ID | Term |
|---|---|
| D013345 | Subarachnoid Hemorrhage |
| D000083242 | Ischemic Stroke |
| ID | Term |
|---|---|
| D020300 | Intracranial Hemorrhages |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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Blood samples
| Background |
| Tso MK, Macdonald RL. Acute microvascular changes after subarachnoid hemorrhage and transient global cerebral ischemia. Stroke Res Treat. 2013;2013:425281. doi: 10.1155/2013/425281. Epub 2013 Mar 25. |
| 20654597 | Background | Friedrich V, Flores R, Muller A, Sehba FA. Luminal platelet aggregates in functional deficits in parenchymal vessels after subarachnoid hemorrhage. Brain Res. 2010 Oct 1;1354:179-87. doi: 10.1016/j.brainres.2010.07.040. Epub 2010 Jul 21. |
| 19623472 | Background | Dankbaar JW, Rijsdijk M, van der Schaaf IC, Velthuis BK, Wermer MJ, Rinkel GJ. Relationship between vasospasm, cerebral perfusion, and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Neuroradiology. 2009 Dec;51(12):813-9. doi: 10.1007/s00234-009-0575-y. Epub 2009 Jul 22. |
| 35989903 | Background | Park SW, Lee JY, Heo NH, Han JJ, Lee EC, Hong DY, Lee DH, Lee MR, Oh JS. Short- and long-term mortality of subarachnoid hemorrhage according to hospital volume and severity using a nationwide multicenter registry study. Front Neurol. 2022 Aug 5;13:952794. doi: 10.3389/fneur.2022.952794. eCollection 2022. |
| 37197995 | Background | Fan J, Li X, Yu X, Liu Z, Jiang Y, Fang Y, Zong M, Suo C, Man Q, Xiong L. Global Burden, Risk Factor Analysis, and Prediction Study of Ischemic Stroke, 1990-2030. Neurology. 2023 Jul 11;101(2):e137-e150. doi: 10.1212/WNL.0000000000207387. Epub 2023 May 17. |
| 34496662 | Background | Naraoka M, Matsuda N, Shimamura N, Ohkuma H. Role of microcirculatory impairment in delayed cerebral ischemia and outcome after aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2022 Jan;42(1):186-196. doi: 10.1177/0271678X211045446. Epub 2021 Sep 9. |
| 27430874 | Background | Frontera JA, Provencio JJ, Sehba FA, McIntyre TM, Nowacki AS, Gordon E, Weimer JM, Aledort L. The Role of Platelet Activation and Inflammation in Early Brain Injury Following Subarachnoid Hemorrhage. Neurocrit Care. 2017 Feb;26(1):48-57. doi: 10.1007/s12028-016-0292-4. |
| 32114386 | Background | Zhou P, Li T, Jin J, Liu Y, Li B, Sun Q, Tian J, Zhao H, Liu Z, Ma S, Zhang S, Novakovic VA, Shi J, Hu S. Interactions between neutrophil extracellular traps and activated platelets enhance procoagulant activity in acute stroke patients with ICA occlusion. EBioMedicine. 2020 Mar;53:102671. doi: 10.1016/j.ebiom.2020.102671. Epub 2020 Feb 27. |
| 34404234 | Background | Coulibaly AP, Pezuk P, Varghese P, Gartman W, Triebwasser D, Kulas JA, Liu L, Syed M, Tvrdik P, Ferris H, Provencio JJ. Neutrophil Enzyme Myeloperoxidase Modulates Neuronal Response in a Model of Subarachnoid Hemorrhage by Venous Injury. Stroke. 2021 Oct;52(10):3374-3384. doi: 10.1161/STROKEAHA.120.033513. Epub 2021 Aug 18. |
| 27040552 | Background | Ishikawa M, Kajimura M, Morikawa T, Tsukada K, Tsuji T, Kusaka G, Tanaka Y, Suematsu M. Leukocyte plugging and cortical capillary flow after subarachnoid hemorrhage. Acta Neurochir (Wien). 2016 Jun;158(6):1057-67. doi: 10.1007/s00701-016-2792-6. Epub 2016 Apr 4. |
| 19240618 | Background | Ishikawa M, Kusaka G, Yamaguchi N, Sekizuka E, Nakadate H, Minamitani H, Shinoda S, Watanabe E. Platelet and leukocyte adhesion in the microvasculature at the cerebral surface immediately after subarachnoid hemorrhage. Neurosurgery. 2009 Mar;64(3):546-53; discussion 553-4. doi: 10.1227/01.NEU.0000337579.05110.F4. |
| 16028769 | Background | Sehba FA, Mostafa G, Friedrich V Jr, Bederson JB. Acute microvascular platelet aggregation after subarachnoid hemorrhage. J Neurosurg. 2005 Jun;102(6):1094-100. doi: 10.3171/jns.2005.102.6.1094. |
| 35973388 | Background | Chen Y, Galea I, Macdonald RL, Wong GKC, Zhang JH. Rethinking the initial changes in subarachnoid haemorrhage: Focusing on real-time metabolism during early brain injury. EBioMedicine. 2022 Sep;83:104223. doi: 10.1016/j.ebiom.2022.104223. Epub 2022 Aug 13. |
| 37212182 | Background | Hoh BL, Ko NU, Amin-Hanjani S, Chou SH-Y, Cruz-Flores S, Dangayach NS, Derdeyn CP, Du R, Hanggi D, Hetts SW, Ifejika NL, Johnson R, Keigher KM, Leslie-Mazwi TM, Lucke-Wold B, Rabinstein AA, Robicsek SA, Stapleton CJ, Suarez JI, Tjoumakaris SI, Welch BG. 2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association. Stroke. 2023 Jul;54(7):e314-e370. doi: 10.1161/STR.0000000000000436. Epub 2023 May 22. |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D020521 | Stroke |