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This study is an anonymous online survey on clinical knowledge of sepsis among healthcare professionals in seven countries in sub-Saharan Africa. The survey is to be repeated every 12-24 months.
The survey is being conducted in the partner countries of the research network "sub-Saharan Africa consorTium for the Advancement of Innovative Research and Care in Sepsis (STAIRS)," which is funded by the German Federal Ministry of Research, Technology and Space (BMFTR). As part of clinical capacity building in partner institutions in Uganda, Ethiopia, the Democratic Republic of the Congo, Mozambique, Ghana, Sierra Leone, and Nigeria, the project will establish a series of webinars and a learning platform, among other things. The survey will be conducted in two separate cross-sectional waves. The baseline survey serves to identify relevant knowledge gaps and determine the needs of various groups of healthcare professionals. The second wave will compare sepsis knowledge scores between waves.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants from the first wave | 150 adult participants from healthcare professions from partner institutions in Uganda, Ethiopia, the Democratic Republic of Congo, Mozambique, Ghana, Sierra Leone, and Nigeria are surveyed. | ||
| Participants from the second wave | 150 adult participants from healthcare professions from partner institutions in Uganda, Ethiopia, the Democratic Republic of Congo, Mozambique, Ghana, Sierra Leone, and Nigeria are surveyed. |
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| Measure | Description | Time Frame |
|---|---|---|
| Sepsis - Knowledge - Score |
| Baseline survey period (January 19, 2026 - April 30, 2026) and follow-up survey period (April 1, 2027 - July 31, 2027) |
| Measure | Description | Time Frame |
|---|---|---|
| Domain-specific knowledge of sepsis | Domain-specific knowledge of sepsis is measured in five domains, to identify specific knowledge gaps. Domain-specific scores will be measured as the sum of correctly answered questions in the questionnaire in respective domain. Domains are:
All domains together sum up to the overall sepsis knowledge score (primary outcome). |
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Inclusion Criteria:
Exclusion Criteria:
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Adult members of a healthcare profession (e.g., doctors, nurses, clinical officers) or their trainees from healthcare facility in one of the seven partner countries (Uganda, Ethiopia, Democratic Republic of the Congo, Mozambique, Ghana, Sierra Leone, Nigeria).
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Claudia Spies, MD, Prof. | Contact | +49 30 450 55 11 02 | claudia.spies@charite.de |
| Name | Affiliation | Role |
|---|---|---|
| Claudia Spies, MD, Prof. | Department of Anesthesiology and Intensive Care Medicine (CCM/CVK), Charité - University Medicine Berlin | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Komfo Anokye teaching hospital | Recruiting | Kumasi | Ghana |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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| Baseline survey period (January 19, 2026 - April 30, 2026), and follow-up survey period (April 1, 2027 - July 31, 2027) |
| Analysis of sepsis knowledge scores and domain-specific scores by professional role |
| Baseline survey period (January 19, 2026 - April 30, 2026), and follow-up survey period (April 1, 2027 - July 31, 2027) |
| Country comparison | • Between group comparison in sepsis knowledge scores and domain-specific sepsis knowledge between different countries (Uganda, Ethiopia, the Demoratic Republic of the Congo, Mozambique, Ghana, Sierra Leone, Nigeria, (potentially other countries in case of spill-over). | Baseline survey period (January 19, 2026 - April 30, 2026), and follow-up survey period (April 1, 2027 - July 31, 2027) |
| Second survey wave only: Change in sepsis knowledge scores between survey waves | - Difference in average knowledge score in repeated survey.
| Follow-up survey period (April 1, 2027 - July 31, 2027) |
| Comparison of sepsis knowledge scores by self-reported participation in capacity-building measures |
| Follow-up survey period (April 1, 2027 - July 31, 2027) |
| Baseline survey only: Self-assessment of perceived training needs |
| Baseline survey period (January 19, 2026 - April 30, 2026) |
| Vignette-based sepsis knowledge score (sum of correct responses to predefined vignette items) |
| Baseline survey period (January 19, 2026 - April 30, 2026), and follow-up survey period (April 1, 2027 - July 31, 2027) |
| D013568 |
| Pathological Conditions, Signs and Symptoms |