Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This project will investigate whether daily snack consumption can improve memory, mood, and overall brain function in people with cognitive impairment. Sixty participants, aged 50 and older, with cognitive impairment, will be randomly assigned to eat snacks, either pecans or pretzels, for three months. Researchers will also study how snacks (pecans and pretzels) may influence the body, including changes in gut bacteria, blood markers of inflammation, and signals that connect the gut and the brain.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pecan | Active Comparator | 2.0 oz pecans daily for 3 months |
|
| Pretzel | Placebo Comparator | 3.5 oz pretzel snack daily for 3 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pecan snack | Biological | Pecan |
| |
| Pretzel snack |
| Measure | Description | Time Frame |
|---|---|---|
| fMRI measures | connectivity of amygdala seed regions and broader bilateral mPFC using fMRI | baseline and after 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| NACC Uniform Data Set | overall neurocognitive functioning | baseline and after 3 months |
| Wisconsin Card Sorting Test | Cognition | baseline and after 3 months |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chwan-Li (Leslie) Shen, PhD | Contact | 806-743-2815 | leslie.shen@ttuhsc.edu |
| Name | Affiliation | Role |
|---|---|---|
| Chwan-Li (Leslie) Shen, PhD | Texas Tech University Health Sciences Center School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Texas Tech University Health Sciences Center | Lubbock | Texas | 79430 | United States |
There is no plan to make IPD available due to HIPAA regulation.
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000090862 | Neuroinflammatory Diseases |
| ID | Term |
|---|---|
| D009422 | Nervous System Diseases |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Biological |
Pretzel snack |
|
| California Verbal Learning Test | Memory and verbal learning | baseline and after 3 months |
| Clock Draw Test | Visuospatial functioning | baseline and after 3 months |
| TRAILS A and B | neuropsychological function | baseline and after 3 months |
| Geriatric Depression Scale (GDS-15) | Depression assessment | baseline and after 3 months |
| Beck Anxiety Inventory (BAI) | Anxiety assessment | baseline and after 3 months |
| fecal zonulin concentration by ELISA | Intestinal permeability marker | baseline and after 3 months |
| gut microbiome | fecal microbiome composition using 16S RNA sequencing | baseline and after 3 months |
| fecal metabolites | untargeted fecal metabolites by LC-MS analysis | baseline and after 3 months |
| neuroinflammation gene | whole blood neuroinflammation gene profiles | baseline and after 3 months |