Mining the gut microbiota of adults for health-relevant microbial signatures.

This study is a community-based, observational cross-sectional investigation, enrolling 1,530 middle-aged and elderly volunteers.

Data were collected through a systematic, multi-dimensional assessment, which included:

Biospecimen Collection: Blood, urine, and stool samples were obtained from the volunteers.

Physical and Imaging Examinations: Procedures included anthropometric measurements, vital sign monitoring, oral examinations, electrocardiograms, physical examinations of key organs, and abdominal ultrasonography.

Psychological and Cognitive Assessments: Standardized scales were administered to assess anxiety/depression and memory function.

All clinical and questionnaire data were processed through standardized procedures, forming a comprehensive health database for subsequent analysis.

Inclusion Criteria：

• Community-dwelling adults aged 30 to 95 years.
• Individuals who underwent an annual health examination at the Health Management Center of Huzhou Central Hospital during the specified time period.
• Ability to comprehend the study content and voluntarily provide signed informed consent.
• Willingness and ability to provide the required biospecimens (blood, urine, stool).

Exclusion Criteria:

• Concurrent participation in another interventional clinical trial that is likely to interfere with the results of this study.
• Voluntary withdrawal from the study.

Meet eligibility criteria