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| Name | Class |
|---|---|
| Claudia Ivette Gamboa Gomez | UNKNOWN |
| Fabian Rojas Larios | UNKNOWN |
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Muscle fatigue caused by physical training is understood as a condition related to the inability to maintain action potential, derived from the alteration in skeletal muscle homeostasis. In long-distance recreational runners, prolonged physical work is performed while maintaining the level of intensity, where a level of fatigue intervenes, which overlaps and generates tiredness to execute the movement continuously. In the last 10 years, sports supplementation has been explored as an aid to increase physical performance, improve muscle recovery and prevent sports injuries.
Objective:
To analyze the effects of an 8-week training program (TP) with vitamin D and branched-chain amino acids (BCAA) supplementation on physical performance and biomarkers of muscle fatigue in long-distance recreational runners.
Materials and methods:
An 8-week randomized controlled clinical trial. Participants will be 64 men aged 25 to 44 years, distributed into 4 intervention groups. Group A: Training + BCAA + Vitamin D. Group B: Training + BCAA + Placebo. Group C: Training + Vitamin D + Placebo. Group D: Training + Placebo + Placebo. Biomarkers of muscle fatigue Interleukin 6 (L-6), Creatine Kinase (CK), Lactate (Lact), Testosterone and Cortisol ratio and serum vitamin D (25(OH)D) and physical performance will be assessed by estimating Maximal oxygen consumption (VO2max) and (Maximal aerobic speed) MAS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 (TP + BCAA + VitD) | Experimental | Training Program + Branched-Chain Amino Acids + Vitamin D |
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| Group 2 (TP + BCAA + P2) | Experimental | Training Program + Branched-Chain Amino Acids + Placebo 2 |
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| Group 3 (TP + VitD + P1) | Experimental | Training Program + Vitamin D (1000 IU) + Placebo 1 |
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| Group 4 (TP + P1+ P2) | Placebo Comparator | Training Program + Placebo1 + Placebo 2 |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Training program | Other | Aerobic training program (60-90% of maximum aerobic speed) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in lactate levels compared to the placebo group | mMol/L | 8 weeks |
| Changes in interleukin-6 levels compared to the placebo group | pg/ml | 8 weeks |
| Changes in cratine kinase levels compared to the placebo group | U/L | 8 weeks |
| Changes in testosterone cortisol ratio compared to the placebo group | mcg/dL | 8 weeks |
| Changes in maximal aerobic speed compared to the placebo group | km/h | 8 weeks |
| Changes in maximal oxygen consumption compared to the placebo group | ml.O2.kg/min | 8 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| MarÃa Zepeda Fuentes, Master of Medical Sciences | Contact | 523121538794 | mzepeda6@ucol.mx |
| Name | Affiliation | Role |
|---|---|---|
| Pedro J Flores Moreno, Doctor of Medical Sciences | Universidad de Colima | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidad de Colima | Colima | Colima | 28040 | Mexico |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22569039 | Background | Howatson G, Hoad M, Goodall S, Tallent J, Bell PG, French DN. Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomized, double-blind, placebo controlled study. J Int Soc Sports Nutr. 2012 Jul 12;9:20. doi: 10.1186/1550-2783-9-20. eCollection 2012. | |
| 32272973 | Background |
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Results and analysis will be shared with other researchers collaborating on the research project.
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In clinical trial types based on their methodology, this protocol is considered a randomized controlled clinical trial. Based on the behavior of its groups, the research is categorized as a parallel group.
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The research is categorized as double-blind parallel groups, the study subjects will be blinded, by not recognizing that they are under supplementation and secondly the principal investigator will also be unaware of the assigned treatment.
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| Branched-Chain Amino Acids | Dietary Supplement | Branched-chain amino acids (5 gr/day) |
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| Vitamin D | Dietary Supplement | Vitamin D (1000 IU/day) |
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| Placebo 1 | Other | Placebo 1 (5gr/day) |
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| Placebo 2 | Other | Placebo 2 (1 tablet/day) |
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| Zebrowska A, Sadowska-Krepa E, Stanula A, Waskiewicz Z, Lakomy O, Bezuglov E, Nikolaidis PT, Rosemann T, Knechtle B. The effect of vitamin D supplementation on serum total 25(OH) levels and biochemical markers of skeletal muscles in runners. J Int Soc Sports Nutr. 2020 Apr 9;17(1):18. doi: 10.1186/s12970-020-00347-8. |
| ID | Term |
|---|---|
| D000597 | Amino Acids, Branched-Chain |
| D014807 | Vitamin D |
| C020845 | P-2 |
| ID | Term |
|---|---|
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D012632 | Secosteroids |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
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