Crystalloid vs Colloid for Hemodynamics During Anesthesia Induction in TAVR Patients

The Impact of Different Preload Strategies on Hemodynamics During Anesthesia Induction in TAVR Patients

The purpose of this study is to evaluate whether the administration of 5 ml/kg of colloid solution prior to anesthesia induction, compared with 5 ml/kg of lactated Ringer's solution, can reduce hemodynamic fluctuations during the induction period (defined as the first 15 minutes after induction) in patients undergoing Transcatheter Aortic Valve Replacement (TAVR).

Inclusion Criteria:

• Age ≥ 18 years;
• Patients scheduled to undergo elective TAVR under general anesthesia;

Exclusion Criteria:

• Allergy to hydroxyethyl starch, its components, and/or sodium lactate Ringer's solution, or a history of colloidal allergy;
• Severe cardiac dysfunction (ejection fraction[EF] < 35%);
• Severe renal dysfunction (creatinine > 132 μg/L and/or requiring renal replacement therapy);
• Morbid obesity (body mass index[BMI] > 37.5 kg/m² or > 32.5 kg/m² with metabolic diseases);
• Severe hepatic dysfunction ;
• Severe electrolyte disturbances ;
• Patients with preoperative intracranial hypertension requiring dehydration therapy;
• Expected postoperative hospital stay < 24 hours;
• Patients scheduled for multiple surgeries during this hospitalization.