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The study aim is to investigate if preoperative volume bolus based on lean body weight could preserve mean arterial pressure during target controlled infusion of anaesthesia (TCI) or rapid sequence induction of anaesthesia (RSI) in non-cardiac, non-morbidly obese surgery.
40 individuals are enrolled to TCI and RSI groups respectively. The randomization process for preoperative fluid bolus prior to induction of anaesthesia is conducted in respective group at the day of surgery. Preoperative colloid fluid therapy (6 ml/kg LBW, Gelofusineâ„¢, Fresenius Kabi Ab, Sweden) is infused rapidly before non-invasive baseline blood pressure (NIBP) measurements in twenty individuals in each group. No other intravenous fluids before induction of anaesthesia.
NIBPs, pulse frequency, peripheral saturation (SpO2) are registered and collected 20 minutes post induction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Preoperative fluids | Experimental | 40 individuals receiving preoperative colloid fluid bolus at 6 ml/kg LBW, (Gelofusineâ„¢, Fresenius Kabi AB, Sweden) before anesthesia induction by TCI (n = 20) or RSI (n =20). |
|
| No preoperative fluids | No Intervention | 40 individuals anesthetized by TCI (n = 20) or RSI (n =20) without preoperative fluids. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| gelofusine | Other | Preoperative colloid fluid bolus 6ml/kg ideal body weight |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of blood pressure drops | blood pressure drop below mean arterial pressure at 65 mmHg during anesthesia induction | 20 minutes post anesthesia induction |
| Effect of preoperative fluid bolus | Does preoperative fluid bolus decrease incidence of blood pressure drops | 20 minutes post anesthesia induction |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Tomi P Myrberg, MD PhD | Umeå University, Norrbotten county concil | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sunderby hospital | Luleå | 97180 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31240711 | Derived | Myrberg T, Lindelof L, Hultin M. Effect of preoperative fluid therapy on hemodynamic stability during anesthesia induction, a randomized study. Acta Anaesthesiol Scand. 2019 Oct;63(9):1129-1136. doi: 10.1111/aas.13419. Epub 2019 Jun 26. |
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| ID | Term |
|---|---|
| D011097 | Polygeline |
| ID | Term |
|---|---|
| D011108 | Polymers |
| D046911 | Macromolecular Substances |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
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Non-blinded randomization. Standardized method comparison.
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| D001697 |
| Biomedical and Dental Materials |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |