To investigate the safety and efficacy of ultrafine cryoprobe biopsy by electromagnetic navigation bronchoscopy compared with biopsy forceps in the diagnosis of peripheral pulmonary nodules in a national multicenter randomized controlled trial

This project intends to carry out a national multicenter randomized controlled study, with traditional forceps biopsy as the control group and cryobiopsy as the experimental group, to verify the feasibility, effectiveness and safety of electromagnetic navigation bronchoscope-guided cryobiopsy in the diagnosis of peripheral pulmonary nodules, so as to provide an efficient and minimally invasive diagnostic method for the diagnosis of peripheral pulmonary nodules

Inclusion Criteria:

1. age 18 to 90 years;
2. pulmonary nodules detected by chest CT, suspected malignant nodules or unknown cause should be confirmed by biopsy;
3. chest CT showed that the nodule was located in the segmental bronchus and below, and the maximum diameter of the nodule was 8 mm to 30 mm.It was not accessible by conventional bronchoscopy;
4. if chest CT showed multiple pulmonary nodules, one of the pulmonary nodules was selected as the target lesion.

Exclusion Criteria:

1. contraindications to the bronchoscopy procedure;
2. high risk of bleeding, such as bronchial artery penetration or suspected lung metastasis of renal cell carcinoma;
3. electromagnetic source implanted in the body;
4. contraindications to anesthesia;
5. pregnant woman;
6. participated in other studies within three months and did not withdraw or finish, affect the observation of this study;
7. inability or unwillingness to provide informed consent or comply with the follow-up schedule.

We will share clinical date.

Data will be available for sharing for 2 years after formal publication of the study.

Researchers working on cryobiopsy and electromagnetic navigation bronchoscopy.