Quality of Life and Functional Outcomes in Laryngeal Cancer Patients

Assessment of Quality of Life, Patient Satisfaction, Swallowing Function, Voice Outcomes, Pain, and Anxiety-Depression at Baseline and at 3-, 6-, and 12-Month Follow-Up in Patients Diagnosed With Laryngeal Squamous Cell Carcinoma: A Prospective Questionnaire-Based Study

Laryngeal squamous cell carcinomas are head and neck malignancies that directly affect both swallowing and voice functions and are associated with a significant deterioration in patients' quality of life throughout the treatment process.

The aim of this study is to evaluate quality of life, voice and swallowing functions, pain, anxiety-depression levels, and patient satisfaction at the pre-treatment period and at the 3rd, 6th, and 12th months post-treatment in patients with laryngeal malignancies, using validated questionnaires, in order to:

Elucidate the course of functional recovery following treatment,

Individualize rehabilitation and follow-up strategies, and

Examine the relationship between functional outcomes and oncological survival.

Inclusion Criteria:

• Age ≥ 18 years at the time of enrollment.
• Histopathologically confirmed diagnosis of laryngeal squamous cell carcinoma.
• Planned to undergo surgical treatment or radiotherapy/chemoradiotherapy as part of standard oncological care.
• Willing and able to participate in the study and to provide written informed consent.
• No history of psychiatric or neurological disorders that could impair comprehension, questionnaire completion, or study participation.

Exclusion Criteria:

• Age < 18 years.
• Presence of comorbid conditions that may independently affect swallowing or voice functions.
• Patients who withdraw consent or request to discontinue participation during or after the treatment period.
• History of psychiatric disorders or use of psychiatric medications that may interfere with study participation or completion of patient-reported outcome measures.