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Anaplasmosis is a bacterial infection caused by the intracellular bacterium Anaplasma phagocytophilum and transmitted by ticks. This bacterium is present in approximately 1% of ticks in Alsace. This infection is responsible for clinical manifestations that are most often mild, including fever, headache, and myalgia, occurring 2 to 3 weeks after a tick bite. However, this infection can be accompanied by potentially serious or even fatal complications, including severe cytopenias, acute respiratory distress syndrome, septic shock, severe neurological disorders, hemorrhagic manifestations, macrophage activation syndrome, and multiple organ failure. Mortality is variable and appears to be higher in American studies, where it is around 4%. Treatment is well-established and relies on doxycycline, which is highly effective. Although a few cases have been described in France, these are mostly isolated cases or short series of cases, whereas Belgium, Poland, and Slovenia have reported numerous cases. Thus, there is a lack of data on French cases, and given that Alsace is in a region with a high prevalence of tick-borne diseases, data is needed to better understand the epidemiology and to better identify suspected cases in order to provide appropriate care.
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| Measure | Description | Time Frame |
|---|---|---|
| Mortality of cases of human anaplasmosis in Alsace | Up to 12 years |
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Inclusion Criteria:
Exclusion Criteria:
- Refusal to participate in the study
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Adult subjct (≥18 years) having a PCR-confirmed infection of Anaplasma
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Victor GERBER, MD | Contact | 33 3.88.11.67.68 | victor.gerber@chru-strasbourg.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service des Maladies Infectieuses et Tropicales - CHU de Strasbourg - France | Recruiting | Strasbourg | 67091 | France |
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| ID | Term |
|---|---|
| D000712 | Anaplasmosis |
| D064927 | Tick Bites |
| D000095542 | Cytopenia |
| D012128 | Respiratory Distress Syndrome |
| D012772 | Shock, Septic |
| D009422 | Nervous System Diseases |
| D055501 | Macrophage Activation Syndrome |
| ID | Term |
|---|---|
| D000711 | Anaplasmataceae Infections |
| D016905 | Gram-Negative Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
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| D007239 | Infections |
| D017282 | Tick-Borne Diseases |
| D000079426 | Vector Borne Diseases |
| D000820 | Animal Diseases |
| D001733 | Bites and Stings |
| D011041 | Poisoning |
| D064419 | Chemically-Induced Disorders |
| D014947 | Wounds and Injuries |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
| D018805 | Sepsis |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012769 | Shock |
| D008232 | Lymphoproliferative Disorders |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |