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Functional movement disorders (FMD) are among the most common neurological conditions seen in clinical practice, yet they are poorly understood and often misdiagnosed. Impaired self-agency, the sense of controlling one's actions, is a key feature of FMD. Studies using functional MRI have shown reduced activation and connectivity in the right inferior parietal lobule, a region associated with agency.
The sense of agency consists of two components: the feeling of agency, which is an implicit, low-level sense of control over voluntary actions, and the judgment of agency, which is the conscious attribution of actions to oneself. While the feeling of agency is often measured using intentional binding tasks, judgment of agency is assessed using self-reported scales. While studies have explored intentional binding as a measure of implicit agency in FMD, few have systematically investigated judgment of agency. This study aims to fill this gap by introducing a novel approach that quantitatively evaluates judgment of agency in FMD patients using action-outcome latencies as an objective metric.
Objective: The objective of this study is to investigate the differences between patients with FMD and healthy controls in perceiving visual and auditory outcomes as consequences of their actions. This will be assessed by measuring their judgment of agency through action-outcome latencies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cases | Functional Movement Disorder | ||
| Controls | Healthy subjects |
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| Measure | Description | Time Frame |
|---|---|---|
| SA Index | Latencies values corresponding to positive ("YES") responses will be extracted. SA (Sense of Agency) Index will be computed by multiplying the 90th percentile latencies by the number of positive responses below this latency threshold and then dividing the result by the total number of responses (positive, negative and unsure) occurring below the same threshold. | Day 1 |
| Latencies | The 90th percentile of latency values among trials with positive ("YES") responses. | Day 1 |
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Inclusion criteria for patients: Inclusion criteria for patients:
Inclusion criteria for healthy subjects:
Exclusion criteria for patients:
Exclusion criteria for healthy subjects:
1. Unable to read and understand English.
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movement disorder clinic
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Aditya Murgai, MBBS MD DM | Contact | 15196633121 | aditya.murgai@lhsc.on.ca |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | London | Ontario | N6A5A5 | Canada |
At this time, IPD will not be shared due to confidentiality concerns.
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| ID | Term |
|---|---|
| D003291 | Conversion Disorder |
| ID | Term |
|---|---|
| D013001 | Somatoform Disorders |
| D001523 | Mental Disorders |
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